Main description:

A vital, comprehensive overview from some of the world's leading researchers and scholars in this field. * Discusses bss-Lactamases and aminoglycoside-modifying enzymes as well as other enzymatic mechanisms that result in resistance. * Covers the different ways bacteria share resistance determinants, both vertically and horizontally. * Offers strategies to control the dissemination of resistance genes and to combat these highly versatile inactivating enzymes. * Serves as a resource for researchers working for clinical research laboratories, hospitals, medical schools, and applied and pharmaceutical research laboratories.

This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Contents:

Table of Contents

A: ENZYMES IN DEFENSE OF THE BACTERIAL RIBOSOME

1. Overview of Aminoglycosides and Enzyme-Mediated Bacterial Resistance: Clinical Implications, Robert A. Bonomo

2. Aminoglycoside Antibiotics, Kanchana Majumder, Lianhu Wei, Subhash C. Annedi, and Lakshmi P. Kotra

3. Structural Aspects of Aminoglycoside-Modifying Enzymes, Gerard D. Wright and Albert M. Berghuis

4. Aminoglycoside-Modifying Enzymes: Characteristics, Localization, and Dissemination, Marcelo E. Tolmasky

5. rRNA Methylases and Resistance to Macrolide, Lincosamide, Streptogramin, Ketolide,
and Oxazolidinone (MLSKO) Antibiotics, Marilyn C. Roberts

B: ENZYMES IN DEFENSE OF THE BACTERIAL CELL WALL

6. B-Lactamases: Historical Perspectives, Karen Bush and Patricia A. Bradford

7. Resistance Mediated by Penicillin-Binding Proteins, Malcolm G. P. Page

8. Inhibition of Class A Beta-Lactamases, Samy O. Meroueh, Jooyoung Cha, and Shahriar Mobashery

9. Class Beta-Lactamases, Gian Maria Rossolini and Jean-Denis Docquier

10. Crystal Structures of Class C B-Lactamases: Mechanistic Implications and Perspectives in Drug Design, C. Bauvois and J. Wouters

11. Class D Beta-Lactamases, Franck Danel, Malcolm G. P. Page, and David M. Livermore

12. A Brief Introduction to Enzyme Kinetics, Moreno Galleni and Jean-Marie Frere

C: NOVEL APPROACHES AND FUTURE PROSPECTS

13. The Pharmaceutical Industry and Inhibitors of Bacterial Enzymes: Implications for Drug Development, David M. Shlaes, Lefa Alksne, and Steven J. Projan

14. Beta-Lactamase Inhibitory Proteins, Zhen Zhang and Timothy Palzkill

15. Active Drug Efflux in Bacteria, Jurg Dreier

D: DISSEMINATION OF ANTIBIOTIC RESISTANCE AND ITS BIOLOGICAL COST

16. Overview of Dissemination Mechanisms of Genes Coding for Resistance to Antibiotics, Marcelo E. Tolmasky

17. Conjugative Transposons, Louis B. Rice

18. The Dissemination of Antibiotic Resistance by Bacterial Conjugation, Virginia L. Waters

19. Bacterial Toxin-Antitoxin Systems as Targets for the Development of Novel Antibiotics, Juan C. Alonso, Dolors Balsa, Izhack Cherny, Susanne K. Christensen, Manuel Espinosa, Djordje Francuski, Ehud Gazit, Kenn Gerdes, Ed Hitchin, M. Teresa Martin, Concepcion Nieto, Karin Overweg, Teresa Pellicer, Wolfram Saenger, Heinz Welfle, Karin Welfle, and Jerry Wells

20. Integrons and Superintegrons, Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer

21. The Biological Cost of Antibiotic Resistance, Dan I. Andersson, Sophie Maisnier Patin, Annika I. Nilsson, and Elisabeth Kugelberg