Main description:

Falciparum Malaria: Diagnostic Tools, Therapeutic Advances, and Future Opportunities discusses the current state of therapeutic options for malaria, antimalarial drugs and drug targets. The book also covers recent progress in the development of vaccines and other approaches for malaria treatment, prevention and control and explores diagnostic tools and biomarkers. Sections examine potential biomarkers and their applications, molecular diagnostic tools, multi-omic approaches for the characterization of therapeutic action of potential new antimalarials, therapeutic advances in falciparum malaria, antimalarial drugs, targeting parasite apicoplast for antimalarial drug discovery, cellular and adjunctive therapies for malaria treatment, and future opportunities.

With contributions from experts in the field, this book is an ideal resource for academics, researchers, graduates and industry engaged in malaria research, its diagnosis, and treatment.

Contents:

Part I: Diagnostics and Biomarkers in Falciparum Malaria 1. Molecular Mechanism of inflammatory signaling pathway in severe malaria pathogenesis 2. Exploration of potential biomarkers and their applications for detection of malaria 3. Laboratory diagnosis of malaria: An update 4. Molecular diagnostic tools in detection of mixed parasitic infections: Current scenario and challenges 5. Multi-omic approaches for characterisation of therapeutic action of potential new antimalarials

Part II: Therapeutic Advances in Falciparum Malaria 6. Antimalarial drugs: Discovery, mechanism of action and drug resistance 7. Targeting parasite apicoplast for antimalarial drug discovery 8. Antimicrobial peptides as a new class of anti-malarial therapeutic agents 9. Investigation of RNA Interference in malaria Parasites 10. Current adjunctive therapy for the treatment of severe and cerebral malaria in humans 11. Cellular therapies for malaria treatment and reduction of malaria induced deaths in endemic regions 12. Malaria diagnostic and treatment: Future opportunities