Main description:

Feldman and Pike's Vitamin D, Fifth Edition, Volume Two: Health, Disease and Therapeutics is the most comprehensive, authoritative reference available, providing investigators, clinicians and students with a definitive, up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. Volume One, Biochemistry, Physiology and Diagnostics presents the advances and new research in the field from the perspective of chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, and diagnosis and management, taking readers through the basic research of vitamin D.

Contents:

Section VII: Population Studies: Vitamin D Deficiency, Nutrition, Sunlight, Genes and Trials 56. Methods of Evaluating Population Studies of Vitamin D: Strengths and Weaknesses; 57. Worldwide Vitamin D Status; 58. Vitamin D in Foods: An Evolution of Knowledge; 59. Determinants of Vitamin D Deficiency from Sun Exposure: A Global Perspective; 60. Vitamin D Fortification and Supplementation Policies to Correct Vitamin D Insufficiency/Deficiency Globally; 61. Vitamin D and Food Fortification; 62. Therapeutic applications of 25-hydroxyvitamin D; 63. Bariatric Surgery, Vitamin D, and Bone Loss; 64. Genetic contribution to vitamin D status; 65. Mendellian randomization in the vitamin D system and human health; 66. Debate: Despite the failure of recent vitamin D supplementation trials, more supplementation studies are required

Section VIII: Disorders 67. Vitamin D Deficiency and Nutritional Rickets in Children; 68. Vitamin D and Osteoporosis; 69. Adult Vitamin D Deficiency: Fracture and Fall Prevention; 70. Randomized Clinical Trials and Bone Health; 71. Clinical Disorders of Phosphate Homeostasis; 72. Vitamin D Hydroxylation-Deficient Rickets, Type 1A: CYP27B1 Mutations; 73. CYP2R1 and Vitamin D-Dependent Rickets Type 1b; 74. Infantile Hypercalcemia and CYP24A1 Mutations; 75. Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets; 76. Vitamin D and Organ Transplantation; 77. The Role of Vitamin D in Type 2 Diabetes Mellitus and D2d Trial; 78. Vitamin D, Obesity, and the Metabolic Syndrome; 79. Liver Metabolism and Disease; 80. Vitamin D, Cardiovascular Disease, and Hypertension + ViDA and VITAL Study; 81. Vitamin D and Renal Disease (including analogs); 82. Idiopathic Hypercalciuria and Nephrolithiasis; 83. Hypercalcemia Due to Vitamin D Toxicity; 84. The Hypocalcemic Disorders; 85. Vitamin D and Paget's Disease

Section IX: Vitamin D Analogs 86. Design and Synthesis of Vitamin D Analogs; 87. Analogs of Calcitriol; 88. Nonsecosteroidal Ligands and Modulators of Vitamin D Receptor; 89. Bile Acid-Derived Vitamin D Receptor Ligands; 90. Bifunctional Vitamin D Hybrid Molecules; 91. Modulating Vitamin D Receptor-Coregulator Binding with Small Molecules; 92. Vitamin D Receptor Antagonists

Section X: Vitamin D and Cancer 93. Overview of Vitamin D Actions in Cancer; 94. Vitamin D Status and Cancer Incidence, Mortality, and Prognosis; 95. Effects of Vitamin D Derivatives on Differentiation, Cell Cycle, and Apoptosis in Hematological Malignancies; 96. Vitamin D Inflammation and Cancer; 97. Vitamin D Actions in Mammary Gland and Breast Cancer: Genomics, Metabolism, and Stem Cells; 98. The Antitumor Effects of Vitamin D in Genitourinary 99 - Vitamin D and Colon Cancer; 100. Vitamin D and Skin Cancer; 102. Sunlight Protection by Vitamin D Compounds

Section XI: Immunity, Infection, Inflammation and Associated Diseases 103. Vitamin D and antibacterial immunity; 104. Vitamin D and antiviral immunity; 105. Vitamin D and Adaptive Immunology in Health and Disease; 106. Vitamin D and the Microbiome; 107. Vitamin D and Tuberculosis; 108. Vitamin D and Type I Diabetes Mellitus; 109. Vitamin D and Immunomodulation in Multiple Sclerosis; 110. Vitamin D and the Epidemiology of Multiple Sclerosis; 111. Vitamin D and Inflammatory Bowel Disease; 112. Vitamin D and Rheumatoid Arthritis; 113. Psoriasis and Other Skin Diseases; 114. Vitamin D, Asthma/Chronic Obstructive Pulmonary Disease; 115. Vitamin D and Acute Illness; 116. Vitamin D and Acute Respiratory Infection; 117. Vitamin D and Covid-19