Main description:

Feldman and Pike's Vitamin D, Fifth Edition, Volume One presents a comprehensive review of the multifaceted vitamin D and provides investigators, clinicians and students with a definitive and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. Written by the most prominent and well-published names in the field, Volume Two: Health, Disease and Therapeutics authoritatively covers evidence of the relationship between vitamin D and diseases, particularly focusing on the results from trials that have been recently published.

Chapters also discuss new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, rheumatoid arthritis, multiple sclerosis, acute illness and Covid-19.

Contents:

Section I: History, Chemistry Metabolism, Circulation and Regulation 1. Historical Overview of Vitamin D; 2. Evolutionary Biology of vitamin D; 3. Photobiology of Vitamin D; 4. The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases); 5. CYP24A1: Structure, Function, and Physiological Role; 6. Alternative Pathways for Vitamin D Metabolism; 7. The Vitamin D-Binding Protein; 8. Regulation of Renal and Extrarenal 1a-Hydroxylase Section II: Mechanism of Action 9. Genome-Wide Perspectives on Vitamin D Receptor-Mediated Control of Gene Expression in Target Cells; 10. Diverse Mechanisms of Transcriptional Regulation by the Vitamin D Receptor; 11. Structural Basis for Ligand Activity in Vitamin D Receptor; 12. Ligand-Independent Actions of Vitamin D Receptor; 13. Vitamin D and Chromatin; 14. Vitamin D, nutrition and epigenetics; 15. Vitamin D and MicroRNAs; 16. OMICS analyses and vitamin D - Pathway analysis and Bioinformatics

Section III: Mineral and Bone Homeostasis 17. Vitamin D Regulation of Osteoblast Function; 18. Osteoclastogenesis and Vitamin D; 19. Vitamin D Activities in Osteocytes; 20. Regulation of Intestinal Calcium and Phosphate Absorption; 21. Cartilage; 22. Vitamin D and Bone: An Integrated Approach; 23. Vitamin D in Dentoalveolar and Oral Health

Section IV: Extra-Skeletal Targets 24. Vitamin D and the Kidney; 25. Vitamin D, the calcium-sensing receptor and the parathyroids; 26. Vitamin D and FGF23; 27. The Role of Vitamin D and Its Receptor in Hair Follicle Biology; 28. Vitamin D, Calcium, and the Epidermis; 29. Vitamin D and the Cardiovascular System; 30. Vitamin D Brain Development and Function; 31. Vitamin D, Vitamin D Receptor, and Adipose Tissue: Focus on Cellular Mechanisms; 32. Vitamin D and Skeletal Muscle; 33. Understanding Vitamin D from Mouse Knockout Models

Section V: Human Physiology 34. Pharmacology and Pharmacokinetics; 35. Fetus, Neonate, lactation and Infant; 36. Vitamin D and the Placenta; 37. Consequences of Perinatal Vitamin D Deficiency on Later Bone Health; 38. Adolescence and Acquisition of Peak Bone Mass; 39. The Role of Vitamin D in Orthopedic Surgery; 40. Vitamin D and Muscle Performance in Athletes and with Ageing; 41. Role in Reproductive Biology and Reproductive Dysfunction in Women; 42. Vitamin D, Reproductive Biology, and Dysfunction in Men; 43. Vitamin D and the Renin-Angiotensin System; 44. Vitamin D: Presence and Function in the Eye; 45. Adult Vitamin D Deficiency and Adverse Brain Outcomes; 46. Vitamin D and the lungs

Section VI: Diagnosis and Management 47. Defining thresholds for vitamin D (different perspectives); 48. Mass Spectrometry Assays of Vitamin D Metabolites; 49. Free Vitamin D: Concepts, Assays, Outcomes, and Prospects; 50. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems, and Interpretation; 51. Detection of 1,25-Dihydroxyvitamin D in Human Serum; 52. Bone Histomorphometry; 53. Radiology of Rickets and Osteomalacia; 54. High-Resolution Imaging Techniques for Bone Quality Assessment; 55. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets