Main description:

Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D.

This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.

Contents:

Volume 1: Biochemistry, Physiology and Diagnostics In Memoriam: Robert P. Heaney, MD (1928-2016) In Memoriam: Milan Uskokovic, PhD (1924-2015)

Section I. History, Chemistry Metabolism, Circulation & Regulation 1. Historical Overview of Vitamin D 2. Evolutionary Biology: Mysteries of Vitamin D in Fish 3. Evolution of Human Skin Color and Vitamin D 4. Photobiology of Vitamin D 5. The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases) 6. CYP24A1: Structure, Function, and Physiological Role 7. The Vitamin D Binding Protein DBP 8. Regulation of renal and extra-renal 1a-hydroxylase

Section II. Mechanism of Action 9. Genome-Wide Perspectives on Vitamin D Receptor-Meditated Control of Gene Expression in Target Cells 10. Diverse mechanisms of transcriptional regulation by the vitamin D receptor 11. Structural basis for ligand activity in VDR 12. Ligand Independent Actions of Vitamin D Receptor 13. Vitamin D and Chromatin 14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions with VDR 15. Vitamin D and microRNAs 16. Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions

Section III. Mineral and Bone Homeostasis 17. Vitamin D Regulation of Osteoblast Function 18. Osteoclastogenesis and Vitamin D 19. Vitamin D Activities in Osteocytes 20. Regulation of Intestinal Calcium and Phosphate Absorption 21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 22. Calcium homeostasis and eggshell biomineralization in female chicken 23. Mineralization in Mammals 24. Cartilage 25. Vitamin D and Bone: An Integrated Approach

Section IV. Extra-Skeletal Targets 26. Vitamin D and the Kidney 27. Vitamin D and the Parathyroids 28. The Calcium-sensing Receptor and Vitamin D 29. Vitamin D in Dentoalveolar and Oral Health 30. The Role of Vitamin D and its Receptor in Hair Follicle Biology 31. Vitamin D, Calcium and the Epidermis 32. Vitamin D and the Cardiovascular System 33. Vitamin D Brain Development and Function 34. Vitamin D, VDR and Adipose Tissue: Focus on Cellular Mechanisms 35. Vitamin D and Skeletal Muscle 36. Understanding Vitamin D from mouse knockout models

Section V. Human Physiology 37. Pharmacology and pharmacokinetics 38. Vitamin D Role in the Calcium and Phosphorus Economies 39. Fetus, Neonate and Infant 40. Consequences of perinatal vitamin D deficiency on later bone health 41. Adolescence and Acquisition of Peak Bone Mass 42. Pregnancy, Lactation, and Post-Weaning Recovery 43. Role in Reproductive Biology and Reproductive Dysfunction in Women 44. Vitamin D, reproductive biology, and dysfunction in men 45. Vitamin D and the Renin-Angiotensin System 46. Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin 47. FGF23 Counter Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and L. Darryl Quarles

Section VI. Diagnosis and Management 48. Approach to the Patient with Metabolic Bone Disease 49. Detection of 1,25-Dihydroxyvitamin D in Human Serum using Receptor Assisted Chemiluminescent Hormone Assay (REACH) Technology 50. Mass Spectrometry Assays of Vitamin D Metabolites 51. Free Vitamin D: Concepts, Assays, Outcomes and Prospects 52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems and Interpretation 53. Bone Histomorphometry 54. Radiology of Rickets and Osteomalcia 55. High-resolution Imaging Techniques for Bone Quality Assessment 56. The Role of Vitamin D in Orthopedic Surgery 57a. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position 57b. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position