Main description:

This book aims to cover the knowledge of protein folding accumulated from studies of disulfide-containing proteins, including methodologies, folding pathways, and folding mechanism of numerous extensively characterized disulfide proteins. Folding of Disulfide Proteins will be valuable supplementary reading for general biochemistry, biophysics, molecular biology, and cellular biology courses for graduate and undergraduate students. This book can also be used for specialized graduate-level biochemistry, biophysics, and molecular biology courses dedicated to protein folding as well as related biological problems and diseases.

Will also be of interest to everybody interested in problems related to protein folding, and anyone who is interested in understanding the mechanism of protein misfolding and protein misfolding-related diseases.

Contents:

1. Oxidative folding: coupling conformational folding and disulfide formation

Salvador Ventura and Jui-Yoa Chang

2. The case of oxidative folding of ribonuclease A: Factors impacting fold maturation of ER-processed proteins

Mahesh Narayan

3. Cystine knot folding in cyclotides

David J. Craik

4. In vitro folding of single chain/double chain insulin and related protein

You-Min Feng

5. Unfolding and refolding of disulfide proteins via disulfide scrambling

Jui-Yoa Chang

6. Small catalysts for Protein oxidative folding

Watson J. Lees

7. Protein Disulfide Isomerase and the Catalysis of Oxidative Protein Folding

Hiram F. Gilbert

8. Allosteric disulfide bonds

Philip J. Hogg

9. The problem of expression of multi-disulfide bonded recombinant protein in E. coli

George Georgiou

10. NMR-spectroscopic investigation of disulfide dynamics in unfolded states of proteins

Harald Schwalbe

11. A half-century of oxidative folding and protein disulfide formation

Robert Freedman