Main description:

This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.

Contents:

Chapter 1. Breast cancer.- Chapter 1.1. Epidemiology.- Chapter 1.2. Etiology.- Chapter 1.3. Types of breast cancer.- Chapter 1.4. Signs and symptoms.- Chapter 1.5. Stages.- Chapter 1.6. Diagnosis.- Chapter 1.7. Treatment.- Chapter 2. Genetic landscape of breast carcinogenesis.- Chapter 2.1. Hormone receptor positive breast cancer.- Chapter 2.1. Her2 positive breast cancer.- Chapter 2.2. Triple negative breast cancer .- Chapter 3. Epigenetic involvement in breast carcinogenesis.- Chapter 3.1. Histone modification.- Chapter 3.2. DNA methylation.- Chapter 3.3. miRNA.- Chapter 4. Breast cancer control.- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer.- Chapter 4.2. Pitfalls of conventional therapy.- Chapter 4.3. Natural remediation.- Chapter 5. Conclusion.