Contributors vii

Preface xiii

SECTION I: BASIC PRINCIPLES AND CONSIDERATIONS OF RATIONAL CHEMOTHERAPY AND MOLECULAR TARGETED THERAPY 1

1 Biologic and Pharmacologic Basis of Cancer Chemotherapy 1
Roland T. Skeel

2 Biologic Basis of Molecular Targeted Therapy 16
Osama E. Rahma and Samir N. Khleif

3 Systematic Assessment of the Patient With Cancer and Consequences of Treatment 45
Roland T. Skeel

4 Selection of Treatment for the Patient With Cancer 63
Roland T. Skeel

SECTION II: CHEMOTHERAPY AND MOLECULAR TARGETED THERAPY OF HUMAN CANCER 69

5 Carcinomas of the Head and Neck 69
Barbara A. Murphy

6 Carcinoma of the Lung 94
David E. Gerber and Joan H. Schiller

7 Carcinomas of the Gastrointestinal Tract 120
Maxwell Vergo and Al B. Benson III

8 Carcinomas of the Pancreas, Liver, Gallbladder, and Bile Ducts 151
Timothy J. Kennedy and Steven K. Libutti

9 Carcinoma of the Breast 172
Patrick Glyn Morris and Clifford A. Hudis

10 Gynecologic Cancer 199
Thomas McNally, Richard T. Penson, Chau Tran, and Michael J. Birrer

11 Urologic and Male Genital Cancers 233
Brendan D. Curti and Craig R. Nichols

12 Kidney Cancer 250
Mark T. Andolina, Colleen Darnell, and Olivier Rixe

13 Thyroid and Adrenal Carcinomas 258
Haitham S. Abu-Lebdeh, Michael E. Menefee, and Keith C. Bible

14 Melanomas and Other Cutaneous Malignancies 277
Ragini Kudchadkar and Jeffrey S. Weber

15 Primary and Metastatic Brain Tumors 297
April Fitzsimmons Eichler and Tracy T. Batchelor

16 Soft-Tissue Sarcomas 310
Robert S. Benjamin

17 Bone Sarcomas 324
Robert S. Benjamin

18 Acute Leukemias 337
Olga Frankfurt and Martin S. Tallman

19 Chronic Leukemias 394
Khaled el-Shami and Bruce D. Cheson

20 Myeloproliferative Neoplasms and Myelodysplastic Syndromes 418
Elias Jabbour and Hagop Kantarjian

21 Hodgkin Lymphoma 437
Richard S. Stein and David S. Morgan

22 Non-Hodgkin Lymphoma 451
Mark Roschewski and Wyndham H. Wilson

23 Multiple Myeloma, Other Plasma Cell Disorders, and Primary Amyloidosis 491
Rachid Baz and Mohamad A. Hussein

24 Metastatic Cancer of Unknown Origin 514
James M. Leonardo

25 HIV-Associated Malignancies 523
Thomas S. Uldrick, Mark N. Polizzotto, and Robert Yarchoan

SECTION III: SUPPORTIVE CARE OF PATIENTS WITH CANCER 543

26 Side Effects of Chemotherapy and Molecular Targeted Therapy 543
Janelle M. Tipton

27 Infections: Etiology, Treatment, and Prevention 566
Thomas J. Walsh and Joan M. Duggan

28 Transfusion Therapy, Bleeding, and Clotting 596
Mary R. Smith and NurJehan Quraishy

29 Oncology Emergencies and Critical Care Issues: Spinal Cord Compression, Cerebral Edema, Superior Vena Cava Syndrome, Anaphylaxis, Respiratory Failure, Tumor Lysis Syndrome, Hypercalcemia, and Bone Metastasis 617
Roland T. Skeel

30 Malignant Pleural, Peritoneal, and Pericardial Effusions and Meningeal Infi ltrates 636
Rekha T. Chaudhary

31 Cancer Pain 649
Richard T. Lee and Michael J. Fisch

32 Emotional and Psychiatric Problems in Patients with Cancer 678
Kristi Skeel Williams and Kathleen S.N. Franco-Bronson

SECTION IV: CHEMOTHERAPEUTIC AND MOLECULAR TARGETED AGENTS AND THEIR USE 693

33 Classification, Use, and Toxicity of Clinically Useful Chemotherapy and Molecular Targeted Therapy 693
Roland T. Skeel

Appendix A:

Surface Area of Adults from Height and Mass 843

Nomogram for Determining BodyAppendix B:

Surface Area of Children from Height and Mass 844

Nomogram for Determining BodyIndex 845