Main description:

This volume of the Handbook of Neurochemistry and Molecular Neurobiology characterizes pathologies resulting from traumatic brain and spinal cord injury as well as various neurodegenerative diseases, demyelinating diseases, viral infection, nervous system tumors, and neuropathies. Special attention is given to mechanisms and pathways of cell death in the brain. The contributors explore and comment on current treatment strategies including facilitating neuroprotection and regeneration and treatment using stem cells.

Feature:

Aims to describe recent discoveries about the basic operations of the brain and spinal coard under moments of trauma.

Provides an introduction to the adaptations for specific types of information processing

The brain is one of the last great frontiers in science

Contents:

Brain Tumor Angiogenesis.- Adrenoleukodystrophy: Molecular, Metabolic, Pathologic And Therapeutic Aspects.- Hyperammonemia.- Glutamate And Cytokine-mediated Alterations Of Phospholipids In Head Injury And Spinal Cord Trauma.- Kynurenines In The Brain: Preclinical And Clinical Studies, Therapeutic Considerations.- Neurofibromatosis Type I: From Genetic Mutation To Tumor Formations.- Amyloid And Neurodegeneration: Alzheimer's Disease And Retinal Degeneration.- Diabetic Retinopathy.- Neurotransmitters And Electrophysiology In Traumatic Brain Injury.- Free Radicals And Neuroprotection In Traumatic Brain And Spinal Cord Injury.- Neuroimmunology Of Paraproteinemic Neuropathies.- Proteolytic Mechanisms Of Cell Death In The Central Nervous System.- Nitric Oxide In Experimental Allergic Encephalomyelitis.- The BBB: Biology, Development And Brain Injury.- Phospholipase A2 In CNS Disorders: Implication On Traumatic Spinal Cord And Brain Injuries.- Axonal Damage Due To Traumatic Brain Injury.- Blood-Central Nervous System Barriers: The Gateway To Neurodegeneration, Neuroprotection And Neuroregeneration.- Engineered Antibody Fragments As Potential Therapeutics Against Misfolded Proteins In Neurodegenerative Diseases.- Pathogenesis And Treatment Of HIV-Associated Dementia: Recent Studies In A SCID Mouse Model.- Stem Cell Transplantation Therapy For Neurological Diseases.- Ubiquitin/Proteasome And Autophagy/Lysosome Pathways: Comparison And Role In Neurodegeneration.- Experimental Autoimmune Encephalomyelitis In The Pathogenesis Of Optic Neuritis: Is Calpain Involved?- Protein Carbonylation In Neurodegenerative And Demyelinating CNS Diseases.- Clinical Considerations In Translational Research With Chronic Spinal Cord Injury: Intervention Readiness And Intervention Impact.- Estrogen As A Promising Multi-Active Agent For The Treatment Of Spinal Cord Injury.- Immunotherapy Strategies For Lewy Body And Parkinson's Disease.- Clinical Outcomes After Spinal Cord Injury.- Spinal Cord Injury ~ A Clinical Perspective.- Cubing The Brain: Mapping Expression Patterns Genome-Wide.