Main description:

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Contents:

Section A: Therapeutic implications of natural compounds

Chapter 1 Natural dietary alkaloids and its synthetic derivatives as oxidative stress-inducing agents for cancer therapy

Chapter 2. Role of antioxidants in the treatment of hepatocellular carcinoma

Chapter 3. Antioxidants in cancer prevention

Chapter 4. Therapeutic potential of natural agents against oxidative stress influenced colitis-associated cancer.

Chapter 5. Prevention of fertility due to chemotherapy-induced ovarian failure: Role of therapeutic antioxidant

Chapter 6 Human papiloma virus (HPV) related cancer, redox state and antioxidant therapy.

Chapter 7. The effect of antioxidants on chemotherapy-induced apoptosis

Chapter 8. Therapeutic potential of Natural antioxidants in Chemotherapeutic Agent Cyclophosphamide Associated Cardiotoxicity

Chapter 9. Therapeutic implications of phytochemicals in ROS induced cancer

Chapter 10. Nutraceuticals in cancer therapy: challenges and opportunities

Chapter 11. Role of dietary antioxidants in chemoprevention of nitrosamines induced carcinogenesis.

Chapter 12 Role of Rosmarinus officinalis (rosemary) essential oil in oxidative stress induced brain cancer

Chapter 13 Therapeutic Flavonoids in cancer: ROS-mediated mechanisms

Chapter 14 Protective effect of Quercetin, Luteolin, and Fisetin via stimulating the p53 mediated signaling in cancer.

Section B: Therapeutic implications of synthetic compounds

Chapter 15. Nitrogen- and sulfur-containing heterocycles as dual anti-oxidant and anti-cancer agents

Chapter 16. Small molecule inhibitors that target signal transduction pathways involved in oxidative stress-induced cancer: current status and future directions.

Chapter 17. Polyphenolic acetates as therapeutics and adjuvant in the therapy of Cancer.

Chapter 18 Application of Peptides as cancer therapeutic

Chapter 19 Retinoids and reactive oxygen species in cancer cell death and therapeutics.

Chapter 20. Benzophenone-2 on oxidative stress induced brain cancer

Chapter 21 Salubrinal promotes cisplatin resistance in human gastric cancer cells via enhabced xCT expression and glutathione biosynthesis.

Chapter 22. Beyond natural antioxidants in cancer therapy: novel synthetic approaches in harnessing oxidative stress.

Chapter 23. Evaluation of chalcore-linked pyrazole pyrimidines in oxidative stress induced breast cancer

Chapter 24. Engineered biopolymer for post operated cancer wound healing

Chapter 25. Role of TNF- inhibitors in oxidative stress induced ovarian cancer

Chapter 26. Oxidative stress induced colon cancer: effect of Tanshienone

Chapter 27. PARP inhibitor olaparib in oxidative stress induced colon cancer

Chapter 28. Prevention of ROS induced gastrointestinal carcinoma by synthetic compounds

Section C : Radiation and photodynamic approaches in ROS induced cancer therapeutics

Chapter 29 Radiotherapy and Oxidative Stress

Chapter 30. Photodynamic therapy induced oxidative stress for cancer treatment.

Chapter 31 Hybrid nanomaterials for photodynamic therapy

Chapter 32. Cross-talk between ROS dependent apoptotic and autophagic signalling pathways in Zn(II) pththalalocyanine photodynamic therapy in melanoma

Chapter 33 Elevating the reactive oxygen species in cancer cells by photodynamic therapy: Pro-oxidative approach for cancer treatment.

Section D: Non-coding RNA in therapeutics of ROS induced cancer

Chapter 34 Oxidative stress mediated miRNA regulation in cancer

Chapter 35 Non-coding RNAs in the regulation of voltage gated anion channels: An emerging aspect of ROS induced cancer therapeutics

Chapter 36. Exosomal non-coding RNAs: A future of therapeutics in regulating oxidative stress induced breast cancer.

Chapter 37 Chapter miRNA and oxidative stress cross talk in cancer

Chapter 38 miRNA-mediated oxidative stress induction in cancer

Chapter 39. miRNA and oxidative stress cross talk in cancer

Chapter 40. A Critical approach in the Analysis of lncRNA characteristics for Cancer Therapy

Chapter 41. Long non coding RNA acting as therapeutic target for oxidative stress induced pancreatic cancer

Chapter 42. Short non-coding RNAs: Emerging molecular players in therapeutics of ROS induced cancer

Section E : Stem cells in therapeutics of ROS induced cancer

Chapter 43. Colon cancer stem cells: Target for treatment of oxidative stress induced colorectal cancer

Chapter 44. Therapeutic modalities regarding ROS in leukemia and hematopoietic stem/progenitor cell perspective

Chapter 45.Stemness and stromal niche: Targets in oxidative stress induced oral cancer

Chapter 46. Targeting developmental pathways in Stem Cell for the therapy of Cancer

Chapter 47. Cancer stem cell oxidative phosphorylation: Target for cancer therapy.

Chapter 48. Targeting oxidative stress specific NRF2 in pancreatic cancer stem cells

Chapter 49. Stem cells in ROS induced cancer therapy.

Section F: Nanotechonology based therapeutics of ROS induced cancer

Chapter 50 Role of natural polyphenols against toxicity induced by oxidative stress in cancer cells.Title: The multifaceted function of nanoparticles in modulating oxidative stress for cancer therapy

Chapter 51. Emerging role of redox active nanoceria in cancer therapeutics via oxidative stress

Chapter 52. Nano technology in ROS induced cancer therapy.

Chapter 53. Nanotechnology-based ROS triggered therapeutic strategies in cancer.

Chapter 54. Nanotechnology in cancer diagnosis and therapy

Chapter 55. Emerging Nano selenium: An insight to its current Status and potentials in ROS induced cancer Prevention and Therapy'

Chapter 56. Oxidative Stress-dependent Anticancer Potentiality of Nano-therapeutic Zinc Oxide

Section G: Bioinformatics and system biology approach for targeting ROS in cancer therapy

Chapter 57 Molecular insights into the roles of E3 ligases in ROS mediated cancer from a bioinformatics perspective

Chapter 58 Elucidation of possible role of heat shock protein as potent therapeutic agent in ROS mediated cancer and its assessment through computational biology methods.

Chapter 59. Dynamical methods to study interaction in proteins facilitating molecular understanding of ROS induced cancer

Chapter 60. Role of Meprin in therapeutics of ROS induced cancer

Chapter 61. Different databases and their utilities to in analyzing ROS mediated cancer

Section H: Other aspects of therapeutics of ROS induced cancer

Chapter 62 A CRISPR-Cas based therapeutics in oxidative stress-induced cancer.

Chapter 63. Role of hypoxia in ROS induced cancer therapy

Chapter 64. Syed Ehtaishamul Haque <

Chapter 65. Molecular mechanism of oxidative stress in cancer and its therapy

Chapter 65. Pro-apoptotic effects of dietary flavonoids in oxidative stress-induced cancer.

Chapter 66. Redox signalling: hallmarks of cancer progression and resistance to treatments

Chapter 67 Mechanistic and therapeutic crosstalk of lipid peroxidation in oxidative stress and breast cancer.

Chapter 68. Targeting Myeloid Leukemia via ROS and Oxidative Stress

Chapter 69. Immunotherapeutic approaches for treatment of oxidative stress in haematological malignancies

Chapter 70 Application of regulating ROS in overcoming cancer multidrug resistance

Chapter 71. Y-Box binding protein 1: A promising therapeutic target for cancer relapses.

Chapter 72. Microbes induced oxidative stress for cancer development and therapeutic role of probiotics

Chapter 73. Implications of ROS in Endometriosis and Ovarian cancer: Potential avenue in cancer therapy.

Chapter 74.Implications of oxidative stress in autophagy and its connection with apoptosis in carcinogenesis

Chapter 75. Role of Forkhead box proteins regulating epithelial mesenchymal transition in breast cancer.