Main description:

This book presents the frontier research of toxicology and health risk assessment of chemicals. First, it provides an overview of the current methods of evaluating safety amounts of chemicals and provides a new aspect of the principle of toxicology. Secondly, it shows recent research where the new method of health risk evaluation is adopted, followed by an integrated health risk assessment of chemicals. Finally, it describes the epigenetic inheritance of chemical impact on health throughout several generations.
Estimating the safety amount of chemicals surrounding our lives is not sufficient for health risk evaluation, particularly for carcinogenic compounds, endocrine disruptors, and nano materials. The author's group has found a family of chemicals linked to ADHD through animal screening and identified its chemical nature using chemoinformatics methods. Based on these new developments, this book proposes to utilize the biomarker common to those chemicals for health risk assessment, independent of exposure routes and physiological dimensions.
The book appeals to researchers and students in the field of toxicology, health risk assessment, pharmacology, and public health.

Contents:

Introduction

Part I: Current methods for estimation of safety amounts of chemicals

Chapter 1. General chemicals
Chapter 2.Carcinogenic chemicals
Chapter 3. Endocrine disruptors
Chapter 4. Nanomaterials
Chapter 5. Epigenetic chemicals

Part II: A new aspect of principle of expression of chemical toxicity

Chapter 6. The action of chemical toxicants
Chapter 7. Three exposure routs of chemicals
Chapter 8. Temporal-Spatial regulation of expression of chemical toxicity Chapter III: Integration of health risk assessment of chemicals

Chapter 9. Animal models for ADHD by chemical exposure
Chapter 10. Epidemiological evidence for ADHD related chemicals
Chapter 11. A common biomarker for health impacts of chemicals, independent of exposure routs
Chapter 12. ADHD related chemicals-its chemical characterization
Preemptive health risk assessment of chemicalsChapter IV: Inheritance of chemical impacts through several generation

Chapter 13. Inheritance of neural disease
Chapter 14. Pioneer work of Dr. Skinner
Chapter 15. Epigenetics
Chapter 16. Epigenetic inheritance of chemical impacts

Chapter 17. Conclusion