Main description:

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. * A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease * An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies * Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics * Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs * Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Contents:

List of contributors xi Preface xxvii Acknowledgments xxix Part 1: INTRODUCTION 1 Cardinal manifestations of cancer 3 James F. Holland, Waun Ki Hong,DonaldW. Kufe, Robert C. Bast Jr.,William N. Hait, Raphael E. Pollock, and Ralph R.Weichselbaum 2 Biological hallmarks of cancer 7 Douglas Hanahan and Robert A.Weinberg Part 2: TUMOR BIOLOGY 3 Molecular biology, genomics, proteomics, and mouse models of human cancer 19 Srinivas R. Viswanathan,David A. Tuveson, and Matthew Meyerson 4 Oncogenes 47 Marco A. Pierotti, Milo Frattini, Francesca Molinari, Gabriella Sozzi, and Carlo M. Croce 5 Tumor suppressor genes 67 David Cosgrove, Ben Ho Park, and Bert Vogelstein 6 Epigenetic contributions to human cancer 85 James G. Herman and Stephen B. Baylin 7 Cancer genomics and evolution 93 William P. D. Hendricks, Aleksandar Sekulic, Alan H. Bryce, Muhammed Murtaza, Pilar Ramos, and Jeffrey M. Trent 8 Chromosomal aberrations in cancer 115 David J. VanderWeele, Megan E. McNerney, and Michelle M. Le Beau 9 MicroRNA expression in cancer 131 Serge Patrick Nana-Sinkam, Mario Acunzo, and Carlo M. Croce 10 Aberrant signaling pathways in cancer 137 Luca Grumolato and Stuart A. Aaronson 11 Differentiation therapy 147 Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, and Zhu Chen 12 Cancer stem cells 159 Yadwinder S. Deol, Jill Granger, and Max S.Wicha 13 Cancer and cell death 167 John C. Reed 14 Cancer cell immortality: targeting telomerase 179 Ilgen Mender, Zeliha Gunnur Dikmen,Woodring E. Wright, and JerryW. Shay 15 Cancer metabolism 187 Natalya N. Pavlova and Craig B.Thompson 16 Modeling therapy of late or early-stage metastatic disease in mice 199 Robert S. Kerbel, Marta Paez-Ribes, ShanMan, Ping Xu, Eric Guerin,William Cruz-Munoz, and John M. L. Ebos 17 Tumor angiogenesis 207 John V. Heymach, Amado Zurita-Saavedra, Scott Kopetz, Tina Cascone, and Monique Nilsson Part 3: QUANTITATIVE ONCOLOGY 18 Cancer bioinformatics 233 John N.Weinstein 19 Systems biology and genomics 247 Saima Hassan, Laura M. Heiser, and JoeW. Gray 20 Statistical innovations in cancer research 255 J. Jack Lee and Donald A. Berry 21 Biomarker-based clinical trial design in the era of genomic medicine 271 Richard Simon and Martine Piccart-Gebhart 22 Clinical informatics 277 Edward P. Ambinder Part 4: CARCINOGENESIS 23 Chemical carcinogenesis 287 Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris 24 Endocrine and genetic bases of hormone-related cancers 307 Leslie Bernstein, Xia Pu, and Jian Gu 25 Ionizing radiation 321 David J. Grdina 26 Ultraviolet radiation carcinogenesis 327 James E. Cleaver, Susana Ortiz-Urda, Radhika Gulhar, Sarah T. Arron, Lionel Brookes 3rd, and David L.Mitchell 27 Inflammation and cancer 333 Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and Michael Karin 28 RNA tumor viruses 341 Robert C. Gallo and Marvin S. Reitz 29 Herpesviruses 353 Jeffrey I. Cohen 30 Papillomaviruses and cervical neoplasia 361 Michael F. Herfs, Martin C. Chang, and Christopher P. Crum 31 Hepatitis viruses and hepatoma 367 HongyangWang, Guangwen Cao, Jing Fu, and Guishuai Lv 32 Parasites 373 Mervat Z. El Azzouni and Radwa G. Diab Part 5: EPIDEMIOLOGY, PREVENTION AND DETECTION 33 The burden of cancer worldwide: current and future perspectives 383 Jacques Ferlay, Christopher P.Wild, and Freddie Bray 34 Cancer epidemiology 399 XifengWu, Xia Pu, Stephanie C. Melkonian, and Margaret R. Spitz 35 Behavioral approaches to cancer prevention 407 Errol J. Philip and Jamie S. Ostroff 36 Diet and nutrition in the etiology and prevention of cancer 415 Steven K. Clinton, Elizabeth M. Grainger, and Edward L. Giovannucci 37 Chemoprevention of cancer 433 William N.William Jr.,Waun Ki Hong, and Scott M. Lippman 38 Cancer screening and early detection 439 OtisW. Brawley Part 6: CLINICAL DISCIPLINES 39 Nexgen pathology: predicting clinical course and targeting disease causation 459 Carlos Cordon-Cardo and Adolfo Firpo-Betancourt 40 Molecular diagnostics in cancer 469 Roshni D. Kalachand, Bryan T. Hennessy, Robert C. Bast Jr., and Gordon B. Mills 41 Principles of imaging 481 Lawrence H. Schwartz 42 Interventional radiology for the cancer patient 483 JudyU. Ahrar, Michael J. Wallace, and Rony Avritscher 43 Principles of surgical oncology 491 Mark Bloomston, Kenneth K. Tanabe, Raphael E. Pollock, and Donald L. Morton (deceased) 44 Principles of radiation oncology 503 Philip P. Connell and Ralph R.Weichselbaum 45 Principles of medical oncology 511 WilliamN. Hait, James F. Holland, Emil Frei III (deceased), DonaldW. Kufe, Robert C. Bast Jr., and Waun Ki Hong 46 Palliative care and pain management 521 Cardinale B. Smith 47 Principles of psycho-oncology 531 Jimmie C. Holland and TaliaW.Wiesel 48 Principles of cancer rehabilitation medicine 537 Michael D. Stubblefield, David C. Thomas, and Kristjan T. Ragnarsson 49 Integrative oncology in cancer care 543 Gabriel Lopez, Richard T. Lee, Alejandro Chaoul, M. Kay Garcia, and Lorenzo Cohen 50 Health services research 549 Michaela A. Dinan, Bradford R. Hirsch, and Amy Abernethy Part 7: INDIVIDUALIZED TREATMENT 51 Personalized medicine in oncology drug development 561 Nicholas C. Dracopoli, Iqbal Grewal, Chris H. Takimoto, and Peter F. Lebowitz Part 8: CHEMOTHERAPY 52 Preclinical and early clinical development of chemotherapeutic drugs, mechanism-based agents and biologics 573 Axel-R. Hanauske and Daniel D. Von Hoff 53 Tumor growth kinetics 589 Elizabeth Comen, Teresa A. Gilewski, and Larry Norton 54 Principles of dose, schedule, and combination therapy 601 William N. Hait and Joseph P. Eder 55 Pharmacology 613 Manish R. Sharma and Mark J. Ratain 56 Folate antagonists 625 Peter D. Cole, Lisa Figueiredo, and Joseph R. Bertino 57 Pyrimidine and purine antimetabolites 637 Robert B. Diasio 58 Alkylating agents and platinum antitumor compounds 649 Zahid H. Siddik 59 DNA topoisomerase targeting drugs 665 AnishThomas, Susan Bates,WilliamD. Figg Sr, and Yves Pommier 60 Agents targeting microtubules and mitotic processes 679 Eric K. Rowinsky 61 Endocrine therapy for hormone receptor-positive breast cancer 713 Aman U. Buzdar, Shaheenah Dawood, Harold A. Harvey, and Virgil Craig Jordan 62 Drug resistance and its clinical circumvention 733 Jeffrey A.Moscow, KennethH. Cowan, and Branimir I. Sikic Part 9: BIOLOGICAL AND GENE THERAPY 63 Cytokines, interferons, and hematopoietic growth factors 743 Suhendan Ekmekcioglu and Elizabeth A. Grimm 64 Monoclonal serotherapy 757 Robert C. Bast Jr., Michael R. Zalutsky, and Arthur E. Frankel 65 Vaccines and immunostimulants 777 Jeffery Schlom, James L. Gulley, and JamesW. Hodge 66 Cell-based cancer immunotherapy 793 Krina K. Patel, Judy S. Moyes, and Laurence J. Cooper 67 Cancer immunotherapy 801 Padmanee Sharma, Sumit K. Subudhi, Karl Peggs, Sangeeta Goswami, Jianjun Gao, Sergio Quezada, and James P. Allison 68 Cancer gene therapy 817 Haruko Tashiro and Malcolm Brenner 69 Cancer nanotechnology 825 Yanlan Liu, Danny Liu, Jinjun Shi, and Robert S. Langer 70 Hematopoietic cell transplantation 831 Roy Jones, Elizabeth Shpall, and Richard Champlin Part 10: SPECIAL POPULATIONS 71 Principles of pediatric oncology 845 Teena Bhatla andWilliam L. Carroll 72 Cancer and pregnancy 865 Jennifer K. Litton 73 Cancer and aging 875 ArtiHurria,Hyman B. Muss, and Harvey J. Cohen 74 Disparities in cancer care 883 OtisW. Brawley 75 Neoplasms in acquired immunodeficiency syndrome 891 Jeremy S. Abramson and David T. Scadden 76 Cancer survivorship: new challenge in cancer medicine 909 Julia H. Rowland Part 11: DISEASE SITES 77 Primary and metastatic neoplasms of the brain in adults 919 Lisa M. DeAngelis 78 Neoplasms of the eye 935 Jasmine H. Francis, Amy C. Schefler, and David H. Abramson 79 Neoplasms of the endocrine glands: pituitary neoplasms 949 Chirag D. Gandhi, Margaret Pain, and Kalmon D. Post 80 Neoplasms of the thyroid 959 Steven I. Sherman, Maria E. Cabanillas, and Stephen Y. Lai 81 Neoplasms of the adrenal cortex 967 Tito Fojo 82 Tumors of the diffuse neuroendocrine and gastroenteropancreatic system 971 Evan Vosburgh 83 Neoplasms of the head and neck 981 Renata Ferrarotto, Merrill S. Kies, Adam S. Garden, and Michael E. Kupferman 84 Cancer of the lung 1011 Charles Lu, Daniel Morgensztern, Anne Chiang, Amir Onn, Boris Sepesi, Ara A. Vaporciyan, Joe Y. Chang, Ritsuko K. Komaki, Ignacio I. Wistuba, and Roy S. Herbst 85 Malignant pleural mesothelioma 1037 Daniel R. Gomez, Anne S. Tsao, Haining Yang, and Harvey I. Pass 86 Thymomas and thymic tumors 1051 Ronan J. Kelly and AlbertoM.Marchevsky 87 Tumors of the heart and great vessels 1063 Anthony F. Yu, Sai-Ching Jim Yeung, Carmen P. Escalante, Sarina van der Zee, A. P. Chahinian, and Valentin Fuster 88 Primary germ cell tumors of the thorax 1069 John D. Hainsworth and F. Anthony Greco 89 Neoplasms of the esophagus 1075 MaxW. Sung, Virginia R. Litle, Steven J. Chmura, Stephen G. Swisher, David C. Rice, Jaffer A. Ajani, Ritsuko K. Komaki, andMark K. Ferguson 90 Carcinoma of the stomach 1091 Carl Schmidt, Mariela Blum Murphy, James C. Yao, and Christopher H. Crane 91 Primary neoplasms of the liver 1103 Junichi Shindoh, KristofferW. Brudvik, and Jean-Nicolas Vauthey 92 Gallbladder and bile duct cancer 1115 Ahmed O. Kaseb, Marc Uemura,Melanie B. Thomas, and Steven A. Curley 93 Neoplasms of the exocrine pancreas 1129 Robert A.Wolff, Christopher H. Crane, Donghui Li, Douglas B. Evans, AnirbanMaitra, and Susan Tsai 94 Neoplasms of the small intestine, vermiform appendix, and peritoneum, and carcinoma of the colon and rectum 1151 Georgia M. Beasley, Zhifei Sun, Daniel P. Nussbaum, and Douglas S. Tyler 95 Neoplasms of the anus 1177 Bruce D. Minsky and Jose G. Guillem 96 Renal cell carcinoma 1187 Earle F. Burgess, Stephen B. Riggs, Brian I. Rini, and Derek Raghavan 97 Urothelial cancer 1195 Derek Raghavan, Richard Cote, Earle F. Burgess, Stephen B. Riggs, and Michael Haake 98 Neoplasms of the prostate 1205 Christopher J. Logothetis, Jeri Kim, JohnW. Davis, Brian F. Chapin, Deborah Kuban, Eleni Efstathiou, and Ana Aparicio 99 Tumors of the penis and the urethra 1237 James F. Holland, Raymond S. Lance, Donald F. Lynch Jr. 100 Testis cancer 1243 Christian Kollmannsberger, Craig R. Nichols, Siamak Daneshmand, Eric K. Hansen, Christopher L. Corless, Bruce J. Roth, and Lawrence Einhorn 101 Neoplasms of the vulva and vagina 1269 Summer B. Dewdney and Jacob Rotmensch 102 Neoplasms of the cervix 1281 Anuja Jhingran and Ana M. Rodriguez 103 Endometrial cancer 1305 Jamal Rahaman, Karen Lu, and Carmel J. Cohen 104 Epithelial ovarian, fallopian tube, and peritoneal cancer 1317 Jonathan S. Berek, Michael L. Friedlander, and Robert C. Bast Jr. 105 Nonepithelial ovarian malignancies 1339 Jonathan S. Berek, Michael L. Friedlander, and Robert C. Bast Jr. 106 Molar pregnancy and gestational trophoblastic neoplasia 1353 Donald P. Goldstein, Ross S. Berkowitz, and Neil S. Horowitz 107 Gynecologic sarcomas 1361 Jamal Rahaman and Carmel J. Cohen 108 Neoplasms of the breast 1369 Hope S. Rugo, Melanie Majure, Anthony Dragun, Meredith Buxton, and Laura Esserman 109 Malignant melanoma 1441 Justin M. Ko, Susan M. Swetter, Jonathan S. Zager, Vernon K. Sondak, Scott E.Woodman, and Kim A. Margolin 110 Other skin cancers 1461 William G. Stebbins, Eric A. Millican, and Victor A. Neel 111 Bone tumors 1475 Timothy A. Damron 112 Soft tissue sarcomas 1499 Robert G. Maki, Chandrajit P. Raut, and Brian O Sullivan 113 The myelodysplastic syndrome 1529 Lewis R. Silverman 114 Acute myeloid leukemia in adults: mast cell leukemia and other mast cell neoplasms 1545 Richard M. Stone and Charles A. Schiffer 115 Chronic myeloid leukemia 1571 Jorge Cortes, Richard T. Silver, and Hagop M. Kantarjian 116 Acute lymphoblastic leukemia 1581 Nitin Jain, Stefan Faderl, Hagop M. Kantarjian, and Susan O'Brien 117 Chronic lymphocytic leukemia 1595 Kanti R. Rai and Jacqueline C. Barrientos 118 Hodgkin lymphoma 1605 Carol S. Portlock, Anita Kumar, and James Armitage 119 Non-Hodgkin s lymphoma 1615 Arnold S. Freedman and Ann S. LaCasce 120 Mycosis fungoides and Sezary syndrome 1629 Richard T. Hoppe, Youn H. Kim, and Ranjana H. Advani 121 Plasma cell tumors 1635 Noopur Raje, Teru Hideshima, Andrew J. Yee, and Kenneth C. Anderson 122 Myeloproliferative neoplasms: essential thrombocythemia, primary myelofibrosis, and polycythemia vera 1659 Ayalew Tefferi Part 12: MANAGEMENT OF CANCER COMPLICATIONS 123 Neoplasms of unknown primary site 1673 John D. Hainsworth and F. Anthony Greco 124 Anorexia and cachexia 1685 Takao Ohnuma 125 Antiemetic therapy 1693 Patrick M. Forde and David S. Ettinger 126 Neurologic complications of cancer 1701 Lisa M. DeAngelis 127 Dermatologic complications of cancer chemotherapy 1717 Anisha B. Patel and Madeleine M. Duvic 128 Skeletal complications 1727 Michael A. Via, Ilya Iofin, and Jeffrey I. Mechanick 129 Hematologic complications and blood bank support 1737 Richard M. Kaufman and Kenneth C. Anderson 130 Coagulopathic complications of cancer patients 1745 Maria T. De Sancho and Jacob H. Rand 131 Urologic complications 1755 Rachel A. Sanford, Ala Abudayyeh, Christopher J. Logothetis, andNizar M. Tannir 132 Cardiac complications 1763 Michael S. Ewer, Steven M. Ewer, andThomas Suter 133 Respiratory complications 1781 Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez, Horiana B. Grosu, Rodolfo C. Morice, Lara Bashoura, Scott E. Evans, Roberto Adachi, Michael Kroll, Saadia A. Faiz, Diwakar D. Balachandran, Selvaraj E. Pravinkumar, and Burton F. Dickey 134 Gastrointestinal and hepatic complications in cancer patients 1807 Robert S. Bresalier, H. Franklin Herlong, and Boris Blechacz 135 Oral complications of cancer and their treatment 1821 Stephen T. Sonis and Anna Yuan 136 Gonadal complications 1833 Vignesh Narayanan and Catherine E. Klein 137 Sexual dysfunction 1843 Leslie R. Schover 138 Endocrine complications and paraneoplastic syndromes 1849 Sai-Ching Jim Yeung and Robert F. Gagel 139 Infections in patients with cancer 1865 Lior Nesher and Kenneth V. I. Rolston 140 Oncologic emergencies 1879 Sai-Ching Jim Yeung and Carmen P. Escalante Part 13: THE FUTURE OF ONCOLOGY 141 A vision for twenty-first century healthcare 1901 Leroy Hood, Kristin Brogaard, and Nathan D. Price Index 1911