Main description:

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert" immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype.

Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition.

There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response.

The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.

Contents:

1. Engineering physical biomaterial properties to manipulate macrophages phenotype: From bench to bedside 2. Early factors in the immune response to biomaterials 3. Nanotechnology and biomaterials for immune modulation and monitoring 4. Immune-instructive materials and surfaces for medical applications 5. Electrospun tissue regeneration biomaterials and immunomodulation 6. Biomaterials and immunomodulation for spinal cord repair 7. Biomaterial strategies to treat autoimmunity and unwanted immune responses to anti-drug antibodies and transplanted tissues 8. Lipids as regulators of inflammation and tissue regeneration 9. Biomaterials modulation of the tumor immune environment for cancer immunotherapy 10. Circumventing immune rejection and foreign body response to therapeutics of type 1 diabetes 11. Machine learning and mechanistic computational modeling of inflammation as tools for designing immunomodulatory biomaterials