Main description:

This book describes a practical approach to the diagnosis, management, and prevention of infectious complications in solid-organ transplant (SOT) candidates and recipients, based on both up-to-date clinical evidence and state of the art expert opinion from world-renowned experts in the field. The book is divided into three parts, the first of which explains risk assessment and the general approach to infectious diseases in the pre-, peri-, and early and late post-transplant periods. The remaining two sections address the prevention and treatment of infection with particular pathogens and the management of specific syndromes, such as pneumonia, CNS infections, UTIs, and skin infections.

Infections in SOT recipients - often due to multidrug-resistant organisms - represent a major challenge. Preventive strategies need to be adapted according to the type of allograft and period after transplantation. Moreover, toxicity and drug interaction with immunosuppressive drugs must be taken into consideration when treating infectious complications. In explaining in depth how best to ensure allograft and patient survival, this book will be of value to infectious disease specialists and transplant physicians at all levels of experience.

Contents:

Section A: general transplant infectious diseases.- 1. Current epidemiology of infection in SOT recipients: a general schedule.- 2. How I assess the risk of infection in SOT recipients.- 3. Pre- and peri- transplant period: screening and treatment of infections in the pre transplant period, donor derived infection.- 4. Early post transplant period. Peri and post transplant preventive strategies. Antiviral, anti-fungal and anti-bacterial prevention.- 5. Late post transplant period. Post transplant vaccination, travel advice, food-borne infections.- Section B: specific pathogens.- 1. How I prevent and treat CMV infection (and other herpesviruses).- 2. How I prevent and treat EBV related complications.- 3. How I prevent and treat polyomavirus infection.- 4. How I prevent and treat respiratory virus infection.- 5. How I prevent and treat viral hepatitis.- 6. How I prevent and treat multi-drug resistant bacterial infection.- 7. How I prevent and treat mold infections.- 8. How I prevent and treat yeast infections.- 9. How I prevent and treat mycobacterial infections.- 10. How I prevent and treat other opportunistic infections: nocardia, toxoplasmosis, pneumocystis, Chagas.- Section C: management of specific syndromes.- 1. Management of pneumonia.- 2. Management of CNS infections.- 3. Management of UTI.- 4. Management of infections of devices: catheter-related infections, pre transplant VAD infections, infections of ECMO devices.- 5. Management of skin infections.