Main description:

This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.

Contents:

1. Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides

Fabienne Danhier, Pierre Danhier, Nathalie Schleich, Chrystelle Po, S. Laurentc, P. Sibret, C. Jerome, V. Poucelle, Bernard Gallez, and Veronique Preat

2. Fabrication of cRGD Conjugated Dual Responsive Micelles to Target v 5 Integrin Overexpressed Cancer

Huacheng He, Remant Bahadur K.C., and Peisheng Xu

3. Copper-Free Click Chemistry Modification of Nanovectors for Integrin Targeted Cancer Therapy

Chang-Fang Wang and Helder A. Santos

4. Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal D

oxorubicin Modified with Different cRGD Peptides

Mohamadreza Amin and Mahmoud Reza Jaafari

5. Preparation of Heterobivalent and Multivalent Radiopharmarmaceuticals to Target Tumors Over-Expressing Integrins

Guillermina Ferro-Flores, Blanca Ocampo-Garcia, Clara Santos-Cuevas, Nallely Jimenez-Mancilla, Myrna Luna-Gutierrez, Flor de M. Ramirez, Enrique Morales-Avila, Luis M. De Leon-Rodriguez, and Erika Azorin-Vega

6. 177Lu Labeled RGD-BBN Peptide for Targeting Prostate Cancer

Lei Jiang and Zhen Cheng

7. Integrin-Mediated Targeting of Liposomally-Bound siRNAs to Tumor Vasculatures

Poulami Ma

jumder and Arabinda Chaudhuri

8. Integrin v 3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide

Hao Hong and Weibo Cai

9. Integrin Targeting Using RGD-Based Peptide Amphiphiles

Poonam Saraf, Xiaoling Li, and Bhaskara Jasti

10. Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting

Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, T. Srinivasa Reddy, Ayan Kumar Barui, Chitta Ranjan Patra, Naidu V.G.M., David J. Adams, and Ramakrishna Sistla

11. Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds Via Integrin Receptors

&n

bsp; Jitka Neburkova, Miroslav Hajek, Ivan Rehor, Jiri Schimer, Frantisek Sedlak, Jan Stursa, Martin Hruby, and Petr Cigler

12. NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780

Ye Kuang, Kunchi Zhang, Min Liu, and Renjun Pei

13. Synergistic Active Targeting to B16F10 Tumors by v 3/CD44-Targeted Nanoparticles Loaded with Docetaxel

Sanjun Shi