Main description:

A current review of basic research on Rickettsiales biology and pathogenesis in one comprehensive volume.

Details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells.
Describes the spectrum of disease caused by an infection including protective and pathologic immune responses.
Describes the latest developments, including genomics and biomathematical modeling, and progress towards genetic tools and a vaccine.
Serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers.

This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Contents:

Table of Contents INTRACELLULAR PATHOGENS II: RICKETTSIALES CONTENTS

1. Clinical Disease: Current Treatment and New Challenges
J. Stephen Dumler
1

2. Public Health: Rickettsial Infections and Epidemiology
Jennifer H. McQuiston and Christopher D. Paddock
40

3. Phylogeny and Comparative Genomics: the Shifting
Landscape in the Genomics Era
Joseph J. Gillespie, Eric K. Nordberg,
Abdu F. Azad, and Bruno W. S. Sobral
84

4. Invasion of the Mammalian Host: Early Events at the
Cellular and Molecular Levels
Juan J. Martinez
142

5. Establishing Intracellular Infection: Escape from the Phagosome
and Intracellular Colonization (Rickettsiaceae)
Matthew D. Welch, Shawna C. 0. Reed, and Cat M. Haglund
154

6. Establishing Intracellular Infection: Modulation of Host
Cell Functions (Anaplasmataceae)
Jason A. Carlyon
175

7. Rickettsial Physiology and Metabolism in the Face of
Reductive Evolution
Jonathon P. Audia
221

8. Innate Immune Response and Inflammation: Roles in
Pathogenesis and Protection (Rickettsiaceae)
Sanjeev K. Sahni, Elena Rydkina, and Patricia J. Simpson-Haidaris
243

9. Innate Immune Response and Inflammation: Roles in
Pathogenesis and Protection (Anaplasmataceae)
Nahed Ismail and Heather L. Stevenson
270

10. Adaptive Immune Responses to Infection
and Opportunities for Vaccine Development (Rickettsiaceae)
Gustavo Valbuena
304

11. Adaptive Immune Responses to Infection
and Opportunities for Vaccine Development (Anaplasmataceae)
Susan M. Noh and Wendy C. Brown
330

12. Persistence and Antigenic Variation
Kelly A. Brayton
366

13. Transmission and the Determinants of Transmission Efficiency
Shane M. Ceraul
391

14. The Way Forward: Improving Genetic Systems
Ulrike G. Munderloh, Roderick F. Felsheim, Nicole Y. Burkhardt, Michael J. Herron,
Adela S. Oliva Chavez, Curtis M. Nelson, and Timothy J. Kurtti
416