Main description:

In this book, actual problems of immune cells interaction with tumours are discussed in terms of the biological kinetics, theoretical biophysics, nonlinear systems and pattern recognition principles. On the basis of the detailed analysis of experimental and clinical data, mathematical models of tumour cells immune recognition mechanisms, co-operative phenomena, immune response dynamics in the whole are described and investigated. Modern mathematical methods are involved in the analysis of the models. Attention is paid to the determination of temporal and quantitative parameters of the ligand-receptor interactions, the processes of tumour cells interaction with different classes of immune cells and monoclonal antibodies.

Contents:

Basic immune reactions and mathematical modelling. Part 1: analysis of kinetic recognition and damaging of target cells at the effector stage of immune response. Part 2: dynamics of local and distributed interaction processes of immune and target cells in vivo. Part 3: structural functional reconstructions of immune homeostasis at the tumour progression.