Main description:

Islet Transplantation: Basic Biology, Immunology and Therapeutic Interventions in Type 1 Diabetes focuses primarily on state-of-the-art strategies for the improvement of islet transplantation methodologies. The book will be solidly built upon the foundation of two sections dedicated to elucidating the new knowledge of the normal biology of pancreatic islet cells and the latest understanding of the genetic, molecular, cellular, and environmental mechanisms involved in the pathophysiology of Type 1 diabetes.

The book is written by internationally-renowned authorities in the field. This will ensure not only the validity and quality of this work, but that the most prominent breakthroughs will be accessed in the most up-to-date manner.

Feature:

- Provides access to the latest experimental data involving islet cell transplantation as a means of establishing endogenous insulin production in type 1 diabetes, and translates this knowledge into a better understanding of where the exciting field of clinical islet transplantation is today, and how it may evolve.

- A multitude of original figures, step-by-step algorithms, imaging studies and detailed tables complement and further illustrate these expert discussions.

Contents:

The origin of islets: development of pancreatic endocrine cells in the human fetus.- Islet cell renewal in the adult human pancreas.- Glucose sensing and normal islet cell function.- Cell signaling of beta cells in the control of insulin secretion.- Beta cell response to other regulatory factors.- Cell-to-cell communication within the islet.- Metabolic profiling of beta cell function.- Modeling of insulin secretion.- Genetics and molecular mechanisms of type 1 diabetes.- Environmental factors contributing to development of type 1 diabetes.- Role of autoimmunity in type 1 diabetes.- Metabolic and hormone derangements in type 1 diabetes.- Long-term complications of type 1 diabetes.- Animal models of type 1 diabetes.- Non-cellular therapies for type 1 diabetes.- Clinical islet cell transplantation.- Donor factors affecting islet yield and function.- Standard islet cell isolation, culture, and quality assessment.- Monitoring of islet graft function.- Monitoring of immune and inflammatory responses to the islet graft.- Alternative sites for islet transplantation.- Islet cryopreservation and banking.- Advanced islet quality assessment.- Embryonic stem cells as a source for generating beta cells.- Adult stem cells as sources for generating beta cells.- Generation of insulin-producing cells from non-pancreatic tissue.- Therapeutic cloning.- Future immunosuppression therapy.- Improving vascularization of the islet graft.- Islet encapsulation.- Islet transplantation from live related donor.- In vivo islet imaging.- Strategies for immune tolerance induction.- Preparation of gene vectors for gene therapy in type 1 diabetes.- Gene therapy and vaccination for type 1 diabetes.- Gene silencing approaches for management and prevention of type 1 diabetes.- Xenotransplantation.- Prevention of type 1 diabetes: evolving strategies