Main description:

This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation.

The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation.

This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.

Contents:

1. Anatomy and Embryology of the Liver.- 2. Liver Histology.- 3. Hepatic Progenitor Cells.- 4. Hepatocellular Death: Apoptosis, Autophagy, Necrosis and Necroptosis.- 5. Steatosis and inflammation in liver pathology.- 6. Molecular basis of fibrogenesis and angiogenesis during chronic liver disease: Impact of TGF- and VEGF on pathogenic pathways.- 7. Hepatotoxicity: Mechanisms of Liver Injury.- 8. Crosstalk of molecular signaling in hepatocellular carcinoma.- 9. Drug-Induced Liver Injury.- 10. Acquired Metabolic Disorders.- 11. Vascular Disorders of the Liver.- 12. Liver Ischaemia Reperfusion Injury.- 13. Autoimmune Hepatitis.- 14. Primary Sclerosing Cholangitis.- 15. Parasitic Diseases of the Liver.- 16. Viral Hepatitis B.- 17. Viral hepatitis C.- 18. Non-B, Non-C Viral Hepatitis.- 19. The Microbiome in Liver Diseases.- 20. Polycystic Liver Diseases.- 21. Portopulmonary Hypertension and Hepatopulmonary syndrome.- 22. HEPATIC ABSCESSES.- 23. Liver Cirrhosis.- 24. Primary Biliary Cholangitis.- 25. The Paucity of Interlobular Bile Ducts.- 26. Nonalcoholic Fatty Liver Disease: a wide spectrum disease.- 27. Alcoholic Liver Disease.- 28. Liver Disease in Pregnancy.- 29. Cirrhotic Cardiomyopathy.- 30. Benign Tumors.- 31. LIVER CANCER.- 32. Acute Liver Failure.- 33. Chronic Liver Failure and Acute-on-Chronic Liver Failure.- 34. History and Physical Examination.- 35. Assessment of Liver Function.- 36. Noninvasive Biomarkers for liver fibrosis.- 37. Peritoneal Fluid Analysis.- 38. Measurement of Hepatic Venous Pressure Gradient (HVPG).- 39. Liver Biopsy for Histopathology.- 40. Abdominal Ultrasonography.- 41. Endoscopy in Hepatic Diseases.- 42. Dynamic and Multi-phase Contrast-enhanced CT Scan.- 43. Patient-specific 3D printing in Liver Disease.- 44. DYNAMIC CONTRAST-ENHANCED ULTRASONOGRAPHY OF THE LIVER.- 45. Ultrasound Elastography.- 46. MR Elastography and Functional MRI of the Liver.- 47. Dynamic Contrast-enhanced MR Imaging.- 48. Transient elastography in chronic liver diseases.- 49. Portal Venography.- 50. Minilaparoscopy and Conventional Laparoscopy.- 51. MEDICAL NUTRITION THERAPY IN LIVER DISEASE.- 52. Molecular Targets in Liver Disease.- 53. Specific Medications for Chronic Viral Hepatitis.- 54. Portal Vein Embolization (PVE) and Partial Transileocolic PVE with Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy-Beyond the Limitations of PVE.- 55. Endoscopic and Pharmacological Treatment of Esophageal Varices.- 56. Procedure for Gastric Variceal Bleeding - From BRTO to PARTO to CARTO, 3 Decades of Progress.- 57. Endoscopy and endoscopic ultrasound for the evaluation and treatment of gastric and ectopic varices.- 58. Portacaval Shunting for Portal Hypertension.- 59. Systemic Therapy of Advanced Liver Cancer.- 60. Embolization Therapy for Liver Cancer.- 61. Ablation of Hepatocellular Carcinoma.- 62. Laparoscopic Liver Resection.- 63. New locoregional approaches to treat liver cancer.- 64. Hepatic Encephalopathy.- 65. Management of ascites.- 66. Extracorporeal Non Cellular Liver Assisted Devices.- 67. Extracorporeal Cellular Liver Assisted Devices.- 68. Liver Transplantation for Acute and Chronic Liver Failure.- 69. Pre and Post Surgical Complications of Liver Transplantation.- 70. Anesthesia in Liver Transplantation.- 71. Surgery in Liver Disease.- 72. Robotic Liver Surgery.- 73. Cardiac surgery risks in liver dysfunction.- 74. Future Approaches in Liver Disorders: Regenerative Medicine.