Main description:

The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver's role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation.

The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs.

A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students.

Contents:

PART 1: Basic Concepts in Liver Immunology

1. Core concepts in immunology, including discussion of innate and adaptive immunity as it relates to liver

2. The liver as a lymphoid organ

3. The definition of autoimmunity and its unique application to the seat of tolerance, the liver

4. The uniqueness of Innate immunity

5. Adaptive immunity and Clinical Definition of Autoantibodies

6. The genetic basis of liver autoimmunity

7. The epigenetic basis of loss of tolerance

8. The gut liver access and the microbiome

PART 2: Clinical Aspects of Liver Immunology

9. Bile acids and bilirubin in liver immunology

10. Use of the Clinical Laboratory

11. The pathologist's approach to reviewing liver histology

12. Bacterial and parasitic diseases of the liver

13. Hepatitis B and Hepatitis D

14. Hepatitis C

15. Other hepatitis virus infections

16. The geoepidemiology of autoimmune liver disease

17. Primary biliary cholangitis

18. Autoimmune hepatitis

19. Primary sclerosing cholangitis

20. Cholestatic variants of autoimmune hepatitis and the concept of overlap

21. IgG4-related diseases

22. Alcoholic liver disease

23. Non-alcoholic fatty liver disease

24. Pediatric liver disease

25. Acute liver failure

26. Immunotherapy and its complications

27. Acute-on-chronic liver failure

28. Drug-induced liver injury

29. Hepatobiliary cancers and immunology

30. Graft-vs-host disease

31. Liver transplantation

32. Immunopathogenesis of liver diseases unique to pregnancy