Main description:

This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.

Contents:

Section 1: Overview

Chapter 1: Introduction and overview

Section 2: Basics of long noncoding RNA Classifications and functions

Chapter 2: The Complexity of the Mammalian Transcriptome

Chapter 3: Towards molecular mechanism in long non-coding RNAs: linking structure and function

Section 3: Long noncoding RNA and inflammation

Chapter 4: Long noncoding RNAs in Rheumatology

Chapter 5: LncRNA and Cardiovascular Disease

Chapter 6: A role for lncRNAs in regulating inflammatory and autoimmune responses underlying type 1 diabetes

Section 4: Long noncoding RNAs as Therapeutic targets

Chapter 7: LncRNA Biomarkers of Inflammation and Cancer

Chapter 8: Functional Implications of Intergenic GWAS SNPs in Immune Related lncRNAs

Chapter 9: Long noncoding RNAs as Therapeutic Targets

Section 5: Challenges and Future Directions

Chapter 10: Challenges and future directions for LncRNAs and inflammation