Main description:

The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders.

Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.

Contents:

Part I Anatomy, Physiology and Pharmacology of Macrophages.- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective.- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective.- Mechanisms and Ways of Macrophage Delivery.- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions.- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems.- Part II Polymeric Nanoparticles for Macrophage Targeting .- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles.- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages.- Surface Modification of Nanoparticles for Macrophage Targeting.- Part III Lipid Nanoparticles for Macrophage Targeting.- Liposomes as Delivery System for Macrophage Targeting.- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages.- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting.- Nanoparticle-based Theranostics for Macrophage-associated Diseases.- Part IV Targeting Macrophages for Treatment of Various Diseases.- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer.- Macrophage Targeting for Therapy of Autoimmune Diseases.- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD).- Macrophage targeting for therapy of intracellular infections.- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases.- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease..- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery.- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery.- Recent Trends in Clinical Studies on Macrophage Targeted Delivery.- Future Directions and Challenges in Macrophage Targeting.