Main description:

This book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, deals with dysregulated host response a relatively new term introduced by the Sepsis-3 definitions in 2016. In contrast to systemic inflammatory response syndrome (SIRS) that has been used for nearly 30 years, this is a fundamentally new concept, which requires some sort of a paradigm shift in the way of thinking of critical care physicians. This change obviously requires time and after 5 years, time is ripe to summarize the knowledge in the form of a comprehensive book.

The book is split in 4 sections. In the first one, the host immune response is explained in 11 chapters, followed by the next part, summarizing the possible tools for assessment at the bedside. The third and the fourth parts focus on the effects of dysregulated immune response on vital organ function and on the possible ways of immunomodulation. Written by internationally acclaimed experts of the field, the book is of value for all those intensivists and allied professionals working in ICUs.

Contents:

Foreword.- Preface.- Part I. The Host Immune Response.- Phenotypes.- The Dysregulated Host Response.- What is Cytokine Storm?.- Hemophagocytic Lymphohistiocytosis.- Extracorporeal Circulation Related Immune response.- Vasoplegic Shock.- Part II. Assessing Dysregulated Immune Response at the Bedside.- Pro- and anti-inflammatory biomarkers.- How to interpret procalcitonin?.- Assessment of the macro-, and microcirculation.- Part III. Dysregulated Immune Response and organ dysfunction.- Heart and circulation.- Brain.- Kidneys.- Liver.- Hemostasis.- The muscles.- Part IV. Modulating the immune response.- The Role of Steroids.- Why did Anti-Cytokine Therapies Fail in the Past?.- Extracorporeal cytokine removal.