Main description:

Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.

Contents:

Chapter-1: Metastasis of breast cancer, an introduction by Robert E. Mansel, Oystein Fodstad and Wen G. Jiang Chapter-2: The genetic control of breast cancer metastasis by Rajeev S. Samant, Oystein Fodstad and Lalita A. Shevde Chapter-3: BRCA1 in initiation, invasion and metastasis of breast cancer: a perspective from the tumor microenvironment by Shaun D. McCullough, Yanfen Hu, and Rong Li Chapter-4: Cell motility and breast cancer metastasis by Marc E. Bracke, Daan De Maeseneer, Veerle Van Marck, Lara Derycke, Barbara Vanhoecke, Olivier De Wever and Herman T. Depypere Chapter-5: Tight junctions and metastasis of breast cancer by Tracey A. Martin Chapter-6: Cell adhesion molecules in breast cancer invasion and metastasis by Lalita A. Shevde and Judy A. King Chapter-7: Endocrine resistance and breast cancer invasion by Stephen Hiscox, Julia Gee and Robert I. Nicholson Chapter-8: The role of aromatase and other oestrogen producing enzymes in mammary carcinogenesis by Mohemmad Salhab and Kefah Mokbel Chapter-9: The role of the HGF regulatory factors in breast cancer by Christian Parr and Wen G. Jiang Chapter-10: The insulin-like growth factor-1 ligand in breast cancer management by Yoon M. Chong, Ash Subramanian and Kefah Mokbel Chapter-11: Lymphangiogenesis and metastatic spread of breast cancer by Mahir A. Al-Rawi and Wen G Jiang Chapter-12: Breast cancer secreted factors alter the bone microenvironment by Valerie A. Siclari, Theresa A. Guise, and John M. Chirgwin Chapter-13: Cyclooxygenease-2 and breast cancer by Gurpreet Singh-Ranger and Kefah Mokbel Chapter-14: Prognostic and predictive factors in human breast cancer by Pamela N. Munster Chapter-15: Molecular imaging in metastatic breast cancer by C.P. Schroeder, G.A.P. Hospers, P.H.B. Willemse, P.J. Perik, E.F.J. de Vries, P.L. Jager, W.T.A. van der Graaf, M.N. Lub-de Hooge, E.G.E. deVries Chapter-16: Detection of disseminated tumor cells in the bone marrow and blood of breast cancer patients by Volkmar Muller and Klaus Pantel Chapter-17: Sentinel lymph node biopsy in early-stage breast cancer by Amit Goyal and Robert E. Mansel Chapter-18: Surgical management of patients with metastatic breast cancer, Adam I. Riker, SuHu Liu, Mona Hagmaier, Matthew J. D. D'Alessio, Charles E. Cox Chapter-19: Therapeutic aspect of metastatic breast cancer, chemotherapy by Robert C.F. Leonard and Thinn P. Pwint Chapter-20: Hormonal therapies of metastatic breast cancer; the past and the present by Jurgen Geisler and Per Eystein Lonning