Main description:

This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described.

In turn, the various aspects of bacterial physiology affected by these signaling systems- e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis - are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior.

Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.

Contents:

Microbial Cyclic Di-Nucleotide Signaling

Editors: Shan-Ho Chou, Nicolas Guiliani, Vincent T. Lee, Ute Roemling

Foreword

Preface

Acknowledgements

Table Of Contents

Part I Biochemistry/Structural Biology - Enzymes

Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria (AnushyaPetchiappan, AvisekMahapa and Dipankar Chatterji) Chapter 2: Structure and regulation of EAL domain proteins (Dom Bellini, Andrew Hutchin, Odel Soren, Jeremy S. Webb, Ivo Tews & Martin A. Walsh) Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins (Julien Lescar) Chapter 4: Structure and function of HD-GYP phosphodiesterases (Serena Rinaldo, Alessandro Paiardini, AlessioPaone, Francesca Cutruzzola, Giorgio Giardina) Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases (Lichuan Gu and Qing He) Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides (Mona W. Orr and Vincent T. Lee)

Part II Biochemistry/Structural Biology - Receptors Chapter 7: Detection of cyclic dinucleotide binding proteins (Vincent T. Lee) Chapter 8: Non-canonical c-di-GMP binding modes (Shan-Ho Chou & Michael Y. Galperin)

Part III Biochemistry/Structural Biology - Sensing

Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction (Hannah Dayton, Marina K. Smiley, Farhad Forouhar, Joe J. Harrison, Alexa Price-Whelan, Lars E.P. Dietrich)

Part IV Cyclic di-AMP biochemistry and physiology

Chapter 10: Metabolic regulation by cyclic di-AMP signaling (Liang Tong, Joshua J. Woodward)

Chapter 11: Osmoregulation via cyclic-di-AMP signaling (Mark S. Turner,Thu Ngoc Minh Vu, Esteban Marcellin,Zhao-Xun Liang and Huong Thi Pham)

Part V Population diversity

Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity (Samuel Miller)

Part VI Cyclic di-GMP and exopolysaccharide regulation

Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP (Jochen Zimmer)

Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling (M. Fata Moradali and Bernd H.A. Rehm)

Part VII Environmental bacteria

Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis (Cordelia A. Weiss and Wade C. Winkler)

Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group (Wen Yin, Lu Liu, Siyang Xu, Jin He)

Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation (Sarah M. Yannarell, Loni Townsley, Elizabeth A. Shank)

Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus (MariaPerez-Burgos & Lotte Sogaard-Andersen)

Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria (Gen Enomoto, Annegret Wilde, and Masahiko Ikeuchi)

Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter (Guoliang Qian, Gaoge Xu, Shan-Ho Chou, Mark Gomelsky, and Fengquan Liu)

Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria (Castro Matias , Diaz Mauricio, Moya-Beltran Ana and Guiliani Nicolas)

Part VIII Pathogens

Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholerae (Erin Young, Garett Bonds, and Ece Karatan)

Chapter 23: Cyclic di-GMP regulation of gene expression (Meng-Lun Hsieh, Deborah M. Hinton, and Christopher M. Waters)

Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium (Ute Roemling)

Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. campestris (Ya-Wen He, Wei Qian, Shan-Ho Chou)

Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis (Yinlan Bai and Guangchun Bai)

Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumoniae (Tiffany M. Zarrella and Guangchun Bai)

Part IX Gram-negative bacteria

Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa (Matthew J. Pestrak and Daniel J. Wozniak)

Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli (Nikola Zlatkov and Bernt Eric Uhlin)

Chapter 30: Cyclic di-GMP in Burkholderia spp (Grace I. Borlee, Mihnea R. Mangalea, and Bradley R. Borlee)

Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion (Karin Sauer)

Part X Cyclic di-GMP signaling in eukaryotes

Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium (Zhi-hui Chen, Christina Schilde and Pauline Schaap)

Part XI Interference Strategies

Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules (Herman O. Sintim and Clement Opoku-Temeng)

Part XII Novel cyclic di-nucleotides

Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes (Todd A. Wright, Andrew B. Dippel, Ming C. Hammond)

Chapter 35: Microbial cyclic GMP-AMP signaling pathways (Miriam S. Ramliden,Geoffrey B. Severin, Brendan J. O'Hara, Christopher M. Watersd, Wai-Leung Ng)

Part XIII Honorary cyclic nucleotides

Chapter 36: 2',3'-cyclic mononucleotide metabolism and possible roles in bacterial physiology (Benjamin M. Fontaine, Yashasvika Duggal, and Emily E. Weinert)

Part XIV Horizontal gene transfer

Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives (Jonas Stenlokke Madsen)

Part XV Conclusion

Chapter 38: Conclusion (Shan-Ho Chou, Nicolas Guiliani, Vincent T. Lee, Ute Roemling, LotteSogaard-Andersen)