Main description:

Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Contents:

Molecular Determinants of Radiation Response

Editors: Theodore L. DeWeese, M.D. and Marikki Laiho, M.D., Ph.D.

Molecular Basis of the DNA Damage Responses

1) H2AX in DNA Damage Response

Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Sedelnikova, and William M. Bonner

2) DNA Damage Signaling Downstream of ATM

Fred Bunz

3) Checkpoint Control Following Radiation Exposure

Markus Lobrich, Aaron A. Goodarzi, Tom Stiff and Penny A. Jeggo

4) Chromatin Responses to DNA Damage

Xuetong Shen and Karina Falbo

5) C. elegans and Radiation Responses

Aymeric Bailly and Anton Gartner

Modulation of Radiation Responses - Opportunities for Therapeutic Exploitation

6) Hypoxia and Modulation of Cellular Radiation Response

Ester M. Hammond, Monica Olcina and Amato J. Giaccia

7) Inhibitors of DNA Repair and Response to Ionising Radiation

Barbara Vischioni, Nils H. Nicolay, Ricky A. Sharma and Thomas Helleday

8) Gene Therapy and Radiation

Svend O. Freytag, Kenneth N. Barton, Farzan Siddiqui, Mohamed Elshaikh,

Hans Stricker and Benjamin Movsas

9) Molecular Targeted Drug Delivery Radiotherapy

Eugenia M. Yazlovitskaya and Dennis E. Hallahan

10) EGFR Signaling and Radiation

Emily F. Dunn, Shyhmin Huang, and Paul M. Harari

11) Thermal Modulation of Radiation-Induced DNA Damage Response

Joseph L. Roti Roti, Robert P. VanderWaal and Andrei Laszlo

12) Radiation-induced Immune Modulation

Charles Drake