Main description:

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type.

The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics.

Contents:

1. Basic pathology and etiology of tumor and its microenvironment 2. EPR effect and its implication in passive targeting of nanocarrier to the tumor 3. pH sensitive carriers as delivery to tumor 4. Temperature sensitive carrier temperature directed tumor cell eradication 5. Magnetically responsive delivery into tumor environment 6. Ligands used for tumor targeting 7. Therapy targeting angiogenic potential of tumor 8. Immunotherapy of cancer 9. Chemical linkers: Potential approach to target tumor 10. Cell penetrating peptide in cancer targeting 11. Inorganic nanoparticles: A new avenue in improving diagnostics 12. Development of photodynamic cancer therapy 13. Therapeutics based on small interfering RNAs (siRNA) 14. Aptamer conjugates: A new avenue 15. Application of cancer stem cells in improving therapeutics 16. Targeting breast cancer 17. Lung cancer: improving efficacy and reducing side effects 18. Colorectal cancer: and its targeting 19. Hepatic cancer targeting 20. Solid tumor: Addressing the problems associated 21. Pancreatic cancer: Removing extracellular matrix barrier in delivery 22. Targeting to the CNS: Approach for brain tumor 23. Metastatic cancer: How one can address the therapeutic challenge 24. Prostate cancer: Delivery aspect and prospect 25. Leukemia: trends in treatment and how close we have achieved eradication 26. Tumor imaging and its application in tumor targeted drug delivery 27. 2D and 3D cell culture: Getting close to mimicking tumor microenvironment in vitro 28. In vivo animal model for cancer: What have we learnt from chemical induced and xenograft models 29. Nanosystem: regulatory aspects, clinical development and market potential