Main description:

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Contents:

PART I : OVERVIEW OF CNS DEVELOPMENT AND DISORDERS.- 1. Overview of CNS Organization and Development.- 2. Neural Induction and Regionalization.- 3. Neural Stem Cells, Differentiation, and Migration.- 4. Neurotrophins and Cell Death.- 5. Synaptogenesis.- 6. Axonal Guidance.- 7. Myelination.- 8. Epigenetics.- 9. The Impact of An Adverse Intrauterine Environment on Neurodevelopment.- 10. Stress as a Determinant of Neurodevelopmental Outcomes.- 11. Sex differences in Neurodevelopment and its Disorders.- PART II : AUTISM SPECTRUM DISORDERS.- 12. The History of Autism Spectrum Disorder.- 13. Epidemiology.- 14. An Approach to the Diagnosis of Autism Spectrum.- 15. Cognition.- 16. The Neuroradiology of Autism: Framing neuroimaging investigations of the autistic brain based on the US NIMH Research Domain Criteria.- 17. Neuropathology of Autism.- 18. Genetics and Epigenetics of ASD.- 19. Preclinical Models of Autism Spectrum Disorder.- 20. Biomedical Interventions for Autism Spectrum Disorder.- 21. Interventions in ASD - Psychosocial Interventions for ASD.- PART III : FETAL ALCOHOL SPECTRUM DISORDER.- 22. Clinical Perspectives on the Diagnostic Assessment of Individuals with FASD.- 23. Epidemiology of alcohol consumption among pregnant and childbearing age women and Fetal Alcohol Spectrum Disorder.- 24. Diagnosis.- 25. Magnetic Resonance Imaging in Fetal Alcohol Spectrum Disorder (FASD).- 26. Neuropathological changes in humans with history of prenatal alcohol exposure or diagnosis of fetal alcohol spectrum disorder.- 27. Genetics and Epigenetics of FASD.- 28. Genetic, Epigenetic, and Environmental Influences on Fetal Alcohol Spectrum Disorder: Implications for Diagnosis, Research and Clinical Practice.- 29. Interventions.- PART IV : CEREBRAL PALSY.- 30. Clinical Vignettes.- 31. Epidemiology.- 32. Diagnosis.- 33. Neuroradiology Of Cerebral Palsy.- 34. Neuropathology Of "Cerebral Palsy".- 35. Genetics and Genomics of Cerebral Palsy.- 36. Pre-Clinical Models of Cerebral Palsy.- 37. Therapeutic Approaches for the Treatment of Cerebral Palsy and Developmental Disability.- PART V : CO-MORBIDITIES IN NEURODEVELOPMENTAL DISORDERS.- 38. Sleep Disorders.- 39. Optimizing Therapy of Seizures in Children and Adolescents with Developmental Disabilities.- 40. Behavioral and Mental Health Disorders (including Attentional Disorders).- 41. Role of Gender and Neurodevelopmental Disabilities.- 42. A non-categorical approach to childhood neurodisability: concepts, evidence and implications for clinical practice, organization of services, teaching, and research.- 43. Pain and Symptom Management in Neurodevelopmental Disorders: Sensory and Nociceptive Function/Pain and Symptom Management.- 44. Pharmacology, Psychopharmacology and Adverse Drug Reactions.- 45. Developmental origins, differential susceptibility and resilience in neurodevelopmental disorders.- PART VI : NEURODEVELOPOMENTAL DISORDERS IN THE CONTEXT OF FAMILIES.- 46. Children with Neurodevelopmental Disabilities and the Right to Health.- 47. Patient Navigation: Core Concepts and Relevance to the Field of Pediatric Neurodisability.- 48. Evaluating the Economic Impact of Neurodevelopmental Disability Intervention on the Family and Community.- PART VII : RESOURCES.- 49. Using Large-Scale Population-Based Data.- 50. Tools for Knowledge Dissemination and Translation to help your journey from research to impact.