Main description:

As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.

Contents:

Preface Ru-Rong Ji, Jianguo Cheng, and Jasmine Ji

Chapter 1 Introduction to Acute, Chronic, and Episodic Pain

Laura Gil and Jianguo Cheng

Chapter 2 Inflammation and Pain

Jasmine Ji. Matthew Yuan, Ru-Rong Ji

Chapter 3 Animal Models of Pain and Anti-inflammatory Treatments

Aidan McGinnis, Michael Wang, Ru-Rong Ji

Chapter 4 Inflammatory Mediators, Nociceptors, and Their Interactions in Pain

Jasmine Ji, Yul Huh, Ru-Rong Ji

Chapter 5 Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons

Jasmine Ji, Yul Huh, Ru-Rong Ji

Chapter 6 Sex Differences in Neuroimmune Interactions and Pain

Xin Luo, Jasmine Ji, Ru-Rong Ji

Chapter 7 Neuroimmune Interactions in Itch

Ouyang Chen, Sreya Rahman, Madelynne Olexa, Jasmine Ji, Ru-Rong Ji

Chapter 8 Toll-like Receptors in Pain and Itch

Amanda S. Andriessen, Elmira Hezarkhani, Christopher R. Donnelly

Chapter 9 Immunotherapy and Pain

Junli Zhao, Alexus Roberts, Ru-Rong Ji

Chapter 10 Cell Therapy and Regenerative Pain Medicine - Preclinical Studies

Toby Chen, Yul Huh, Andrew Breglio

Chapter 11 Cell-based Therapies in Pain Management

Jianguo Cheng

Chapter 12 Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain

Thomas Buchheit

Chapter 13 Exercise and Diet in the Control of Inflammation and Pain

Jasmine Ji, Aidan McGinnis, Ru-Rong Ji

Chapter 14 Mechanism-Based Pain Therapies

Raissa Quezado da Nobrega, Ru-Rong Ji, Jianguo Cheng

Chapter 15 Neuromodulation in Pain Management

Paul Guillod, Jianguo Cheng

Chapter 16 What Patients Need to Know about Pain Therapy?

Ellen W. K. Rosenquist