Main description:

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Contents:

Preface. Editors. Contributors. Endogenous Activation and Neurophysiological Functions of Acid-Sensing Ion Channels. Acid-Sensing Ion Channels and Synaptic Plasticity: A Revisit. Trimeric Scaffold Ligand-Gated Ion Channels. Eukaryotic Mechanosensitive Ion Channels. Ion Channels in Human Pluripotent Stem Cells and Their Neural Derivatives. Exocytosis of Nonclassical Neurotransmitters. Nonclassical Ion Channels in Learning and Memory. Neuropeptide Regulation of Ion Channels and Food Intake. Prefrontal Inhibitory Signaling in the Control of Social Behaviors. Studying Brain Function Using Non-human Primate Models. Application of In Vivo Ca2+ Imaging in the Pathological Study of Autism Spectrum Disorders. Nonclassical Ion Channels in Depression. Ion Channels of Reward Pathway in Drug Abuse. Ion Channel Conformational Coupling in Ischemic Neuronal Death. Nonclassical Ion Channels and Ischemia. Transient Receptor Potential Channels and Itch. Two-Pore Domain Potassium Channels in Pain and Depression. Lysosomal Ion Channels and Human Diseases. Microglial Voltage-Gated Proton Channel Hv1 in Neurological Disorders. Index.