Main description:

From the 39th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Washington, DC, USA in July 2011, this volume covers aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence. Oxygen Transport to Tissue XXXIV includes contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians.

Contents:

1. Britton Chance (1913 - 2010): His Life, Times, and Legacy as A Scientist, Engineer, Inventor, Educator, Athlete, Patriot, Philosopher, and an Excellent ISOTT Member

Lin Z. Li, Shoko Nioka, and Kyung A. Kang

2. Effects of Experimentally Deviated Mandibular Position on Stress Response

Ai Amemiya, Tomotaka Takeda, Kazunori Nakajima, Keiichi Ishigami, Takeo Tsujii, and Kaoru Sakatani

3. Kidney EPO Expression during Chronic Hypoxia in Aged Mice

Girriso F. Benderro, and Joseph C. LaManna

4. Nature's "Silver Bullet" for Anticoagulation: Mechanism of Zymogen Protein C to Activated Protein C

Duane F. Bruley, and Michael B. Streiff

5. Canonical Correlation Analysis in the Study of Cerebral and Peripheral Haemodynamics Interrelations with Systemic Variables in Neonates Supported on ECMO

Alexander Caicedo, Maria D. Papademetriou, Clare E. Elwell, Aparna Hoskote, Martin J. Elliott, Sabine Van Huffel, and Ilias Tachtsidis

6. Blood Oxygen Level Dependent Magnetization Transfer (BOLDMT) Effect

Kejia Cai, Mohammad Haris, Anup Singh, Lin Z. Li, and Ravinder Reddy

7. Characterizing Prostate Tumor Mouse Xenografts with CEST & MT MRI and Redox Scanning

Kejia Cai, He N. Xu, Anup Singh, Mohammad Haris, Ravinder Reddy, and Lin Z. Li

8. In vitro Sirius Red Collagen Assay Measures the Pattern Shift From Soluble to Deposited Collagen

Chun Chen, Shanmin Yang, Mei Zhang, Zhenhuan Zhang, Bingrong Zhang, Deping Han, Jun Ma, Xiaohui Wang, Jingshen Hong, Yansong Guo, Paul Okunieff, and Lurong Zhang

9. Intravoxel Incoherent Motion MR Imaging of the Kidney. Pilot study.

Per Eckerbom, Peter Hansell, Tomas Bjerner, Fredrik Palm, Jan Weis, and Per Liss

10. Changes in Gastric Mucosa, Submucosa & Muscularis IC pH May Herald Irreversible Tissue Injury

Elaine M. Fisher, Sheau Huey Chiu, and Joseph C. LaManna

11. Normobaric Hyperoxia Does Not Change Optical Scattering or Pathlength but Does Increase Oxidised Cytochrome c Oxidase Concentration in Patients with Brain Injury

Arnab Ghosha, Ilias Tachtsidis, Christina Kolyva, David Highton, Clare Elwell, and Martin Smith

12. Multi-frequency Forced Oscillation Technique using Impulse Oscillations - Can it give Mechanical Information about the Lung Periphery?

Hiroshi Hamakawa, Hiroaki Sakai, Ayuko Takahashi, Toru Bando, and Hiroshi Date

13. NIRS Measurements with Elite Speed Skaters: Comparison between the Ice Rink and the Laboratory

Catherine Hesford, Marco Cardinale, Stewart Laing and Chris E. Cooper

14. Modelling Cerebrovascular Reactivity: A Novel Near Infrared Biomarker of Cerebral Autoregulation?

David Highton, Jasmina Panovska-Griffiths, Arnab Ghosh, Ilias Tachtsidis, Murad Banaji, Clare Elwell, and Martin Smith

15. Oxygen Delivery Deficit in Exercise with Rapid Ascent to High Altitude

Luke Holdsworth, and Christopher Wolff

16. Oscillations in Cerebral Hemodynamics in Patients with Falciparum Malaria

Christina Kolyva, Hugh Kingston, Ilias Tachtsidis, Sanjib Mohanty, Saroj Mishra, Rajya Patnaik, Richard J. Maude, Arjen M. Dondorp, and Clare E. Elwell

17. Effect of Spinal Anesthesia for Elective Cesarean Section on Cerebral Blood Oxygenation Changes: Comparison of Hyperbaric and Isobaric Bupivacaine

Yuko Kondo, Kaoru Sakatani, Noriya Hirose, Takeshi Maeda, Jitsu Kato, Setsuro Ogawa, and Yoichi Katayama

18. DCX-expressing Neurons Decrease in the Retrosplenial Cortex after Global Brain Ischemia

Nobuo Kutsuna, Yoshihiro Murata, Takashi Eriguchi, Yoshiyuki Takada, Hideki Oshima, Kaoru Sakatani, and Yoichi Katayama

19. Calibration and Validation Scheme for In Vivo Spectroscopic Imaging of Tissue Oxygenation

Maritoni Litorja, Robert Chang, Jeeseong Hwang, David W. Allen, Karel Zuzak, Eleanor Wehner, Sara Best, Edward Livingston, and Jeffrey Cadeddu

20. Considering the Vascular Hypothesis of Alzheimer's Disease: Effect of Copper Associated Amyloid on Red Blood Cells

Heather R. Lucas, and Joseph M. Rifkind

21. The Role of Mitochondrial Proteomic Analysis in Radiological Accidents and Terrorism

David Maguire, Bingrong Zhang, Amy Zhang, Lurong Zhang, and Paul Okunieff

22. Alteration of Plasma Galactose/N-acetylgalactosamine Level after Irradiation

Jun Ma, Deping Han, Mei Zhang, Chun Chen, Bingrong Zhang, Zhenhuan Zhang, Xiaohui Wang, Shanmin Yang, Yansong Guo, Paul Okunieff, and Lurong Zhang

23. Fibroblast Growth Factor-peptide Promotes Bone Marrow Recovery after Irradiation

Jun Ma, Yanqian Hou, Deping Han, Mei Zhang, Chun Chen, Bingrong Zhang, Zhenhuan Zhang, Xiaohui Wang, Shanmin Yang, Yansong Guo, Paul Okunieff, and Lurong Zhang

24. Dynamic Two-Photon Imaging of Cerebral Microcirculation Using Fluorescently Labeled Red Blood Cells and Plasma

Kazuto Masamoto, Hiroshi Kawaguchi, Hiroshi Ito, and Iwao Kanno

25. The Effect of Basic Assumptions on the Tissue Oxygen Saturation Value of Near Infrared Spectroscopy

Andreas Jaakko Metz, Martin Biallas, Carmen Jenny, Thomas Muehlemann, and Martin Wolf

26. The Effect of Sudden Depressurization on Pilots at Cruising Altitude

Thomas Muehlemann, Lisa Holper, Juergen Wenzel, Martin Wittkowski, and Martin Wolf

27. Hypoxia in the Diabetic Kidney is Independent of Advanced Glycation End-products

Lina Nordquist, Per Liss, Angelica Fasching, Peter Hansell, and Fredrik Palm

28. Tumor Oxygen Measurements and Personalized Medicine

Paul Okunieff, Walter O'Dell, Mei Zhang, Lurong Zhang, and David Maguire

29. Wavelet Cross-Correlation to Investigate Regional Variations in Cerebral Oxygenation in Infants supported on Extra-Corporeal Membrane Oxygenation

Maria Papademetriou, Ilias Tachtsidis, Martin J. Elliott, Aparna Hoskote, and Clare E. Elwell

30. Association of the Red Cell Distribution Width with Red Blood Cell Deformability

Kushang V. Patel, Joy G. Mohanty, Bindu Kanapuru, Charles Hesdorffer, William B. Ershler, and Joseph M. Rifkind

31. Kidney Function after In Vivo Gene Silencing of Uncoupling Protein-2 in Streptozotocin-induced Diabetic Rats

Malou Friederich Persson, William J. Welch, Christopher S. Wilcox, and Fredrik Palm

32. Adenosine A2 Receptor-mediated Regulation of Renal Hemodynamics and Glomerular Filtration Rate is Abolished in Diabetes

Patrik Persson, Peter Hansell, and Fredrik Palm

33. Can Mitochondrial Cytochrome Oxidase Mediate Hypoxic Vasodilation via Nitric Oxide Metabolism?

Zimei Rong, Murad Banaji, Tracy Moroz, and Chris E. Cooper

34. Effects of Occlusal Disharmony on Working Memory Performance and Prefrontal Cortex Activity Induced by Working Memory Tasks Measured by NIRS

Kaoru Sakatani, Takeo Tsujii, Teruyasu Hirayama, Youichi Katayama, Tomotaka Takeda, Ai Amemiya, and Keiichi Ishigami

35. Biological Maintenance of Distal Vein Arterialization

Tadahiro Sasajima, and Tomiyasu Koyama

36. Bayesian STAI Anxiety Index Predictions Based on Prefrontal Cortex NIRS Data for the Resting State

Masakaze Sato, Wakana Ishikawa, Tomohiko Suzuki, Takashi Matsumoto, Takeo Tsujii, and Kaoru Sakatani

37. The Effect of Venous and Arterial Occlusion of the Arm on Changes in Tissue Blood Flow/Volume, Oxygenation and Ultra-weak Photon Emission

Felix Scholkmann, Olaf Schraa, Roeland van Wijk, and Martin Wolf

38. Metabolic Network Analysis of DB1 Melanoma Cells: How much Energy is Derived from Aerobic Glycolysis?

A.A. Shestov, A. Mancuso, D. B. Leeper, and J. D. Glickson

39. Muscle Oxygen Saturation Heterogeneity among Leg Muscles during Ramp Exercise

Shun Takagi, Ryotaro Kime, Masatsugu Niwayama, Norio Murase, and Toshihito Katsumura

40. PET-imaging of the Impact of Extracellular pH and MAP Kinases on the p-glycoprotein (Pgp) Activity

Oliver Thews, Wolfgang Dillenburg, Frank Roesch, and Marco Fellner

41. Meconium and Transitional Stools May Cause Interference with Near-Infrared Spectroscopy Measurements of Intestinal Oxygen Saturation in Preterm Infants

Alecia Thompson, Paul Benni, Sara Seyhan, and Richard Ehrenkranz

42. Acute Effects of Physical Exercise on Prefrontal Cortex Activity in Older Adults: A Functional Near-Infrared Spectroscopy Study

Takeo Tsujii, Kazutoshi Komatsu, and Kaoru Sakatani

43. Blood Flow and Oxygenation Status of Prostate Cancers

Peter Vaupel, and Debra K. Kelleher

44. Targeted Delivery of VEGF to Treat Myocardial Infarction

Bin Wang, Rabe'e Cheheltani, Jenna Rosano, Deborah L. Crabbe, and Mohammad F. Kiani

45. Magnetic Nanoparticles and Thermally-Responsive Polymer for Targeted Hyperthermia and Sustained Anti-Cancer Drug Delivery

Sarah Y. Wang, Michelle C. Liu, and Kyung A. Kang

46. NIR Fluorophore-Hollow Gold Nanosphere Complex for Cancer Enzyme Triggered Detection and Hyperthermia

Jianting Wang, Damon Wheeler, Jin Z. Zhang, Samuel Achilefu, and Kyung A. Kang

47. Renal Oxygenation and Function of the Rat Kidney: Effects of Inspired Oxygen and Preglomerular Oxygen Shunting

Christopher S. Wilcox, Fredrik Palm, and William J. Welch

48. Alteration of the Inflammatory Molecule Network after Irradiation of Soft Tissue

Zhenyu Xiao, Shanmin Yang, Ying Su, Wei Wang, Hengshan Zhang, Mei Zhang, Kunzhong Zhang, Yeping Tian, Yongbing Cao, Liangjie Yin, Lurong Zhang, and Paul Okunieff

49. Imaging the Redox States of Human Breast Cancer Core Biopsies

H. N. Xu, J. Tchou, B. Chance, and L. Z. Li

50. Early Life Hypoxic or Hypoxic/hypercapnic Stress Alters Acute Ventilatory Sensitivity in Adult Mice

Kui Xu, Solomon Raju Bhupanapadu Sunkesula, Pengjing Huang, Constantinos P. Tsipis, Thomas Radford, Gerald Babcock, Walter F. Boron, and Joseph C. LaManna

51. 3D Analysis of Intracortical Microvasculature during Chronic Hypoxia in Mouse Brain

Kouichi Yoshihara, Hiroyuki Takuwa, Iwao Kanno, Shinpei Okawa, Yukio Yamada, and Kazuto Masamoto

52. Contribution of Brain Glucose and Ketone Bodies to Oxidative Metabolism

Yifan Zhang, Youzhi Kuang, Joseph C. LaManna, and Michelle A. Puchowicz

53. Alteration of Circulating Mitochondrial DNA Concentration after Irradiation

Mei Zhang, Bingrong Zhang, Yansong Guo, Lei Zhang, Shanmin Yang, Liangjie Yin, Sadasivan Vidyasagar, David Maguire, Steve Swarts, Zhenhuan Zhang, Amy Zhang, Lurong Zhang, and Paul Okunieff

5. Canonical Correlation Analysis in the Study of Cerebral and Peripheral Haemodynamics Interrelations with Systemic Variables in Neonates Supported on ECMO

Alexander Caicedo, Maria D. Papademetriou, Clare E. Elwell, Aparna Hoskote, Martin J. Elliott, Sabine Van Huffel, and Ilias Tachtsidis

6. Blood Oxygen Level Dependent Magnetization Transfer (BOLDMT) Effect

Kejia Cai, Mohammad Haris, Anup Singh, Lin Z. Li, and Ravinder Reddy

7. Characterizing Prostate Tumor Mouse Xenografts with CEST & MT MRI and Redox Scanning

Kejia Cai, He N. Xu, Anup Singh, Mohammad Haris, Ravinder Reddy, and Lin Z. Li

8. In vitro Sirius Red Collagen Assay Measures the Pattern Shift From Soluble to Deposited Collagen

Chun Chen, Shanmin Yang, Mei Zhang, Zhenhuan Zhang, Bingrong Zhang, Deping Han, Jun Ma, Xiaohui Wang, Jingshen Hong, Yansong Guo, Paul Okunieff, and Lurong Zhang

9. Intravoxel Incoherent Motion MR Imaging of the Kidney. Pilot study.

Per Eckerbom, Peter Hansell, Tomas Bjerner, Fredrik Palm, Jan Weis, and Per Liss

10. Changes in Gastric Mucosa, Submucosa & Muscularis IC pH May Herald Irreversible Tissue Injury

Elaine M. Fisher, Sheau Huey Chiu, and Joseph C. LaManna

11. Normobaric Hyperoxia Does Not Change Optical Scattering or Pathlength but Does Increase Oxidised Cytochrome c Oxidase Concentration in Patients with Brain Injury

Arnab Ghosha, Ilias Tachtsidis, Christina Kolyva, David Highton, Clare Elwell, and Martin Smith

12. Multi-frequency Forced Oscillation Technique using Impulse Oscillations - Can it give Mechanical Information about the Lung Periphery?

Hiroshi Hamakawa, Hiroaki Sakai, Ayuko Takahashi, Toru Bando, and Hiroshi Date

13. NIRS Measurements with Elite Speed Skaters: Comparison between the Ice Rink and the Laboratory

Catherine Hesford, Marco Cardinale, Stewart Laing and Chris E. Cooper

14. Modelling Cerebrovascular Reactivity: A Novel Near Infrared Biomarker of Cerebral Autoregulation?

David Highton, Jasmina Panovska-Griffiths, Arnab Ghosh, Ilias Tachtsidis, Murad Banaji, Clare Elwell, and Martin Smith

15. Oxygen Delivery Deficit in Exercise with Rapid Ascent to High Altitude

Luke Holdsworth, and Christopher Wolff

16. Oscillations in Cerebral Hemodynamics in Patients with Falciparum Malaria

Christina Kolyva, Hugh Kingston, Ilias Tachtsidis, Sanjib Mohanty, Saroj Mishra, Rajya Patnaik, Richard J. Maude, Arjen M. Dondorp, and Clare E. Elwell

17. Effect of Spinal Anesthesia for Elective Cesarean Section on Cerebral Blood Oxygenation Changes: Comparison of Hyperbaric and Isobaric Bupivacaine

Yuko Kondo, Kaoru Sakatani, Noriya Hirose, Takeshi Maeda, Jitsu Kato, Setsuro Ogawa, and Yoichi Katayama

18. DCX-expressing Neurons Decrease in the Retrosplenial Cortex after Global Brain Ischemia

Nobuo Kutsuna, Yoshihiro Murata, Takashi Eriguchi, Yoshiyuki Takada, Hideki Oshima, Kaoru Sakatani, and Yoichi Katayama

19. Calibration and Validation Scheme for In Vivo Spectroscopic Imaging of Tissue Oxygenation

Maritoni Litorja, Robert Chang, Jeeseong Hwang, David W. Allen, Karel Zuzak, Eleanor Wehner, Sara Best, Edward Livingston, and Jeffrey Cadeddu

20. Considering the Vascular Hypothesis of Alzheimer's Disease: Effect of Copper Associated Amyloid on Red Blood Cells

Heather R. Lucas, and Joseph M. Rifkind

21. The Role of Mitochondrial Proteomic Analysis in Radiological Accidents and Terrorism

David Maguire, Bingrong Zhang, Amy Zhang, Lurong Zhang, and Paul Okunieff

22. Alteration of Plasma Galactose/N-acetylgalactosamine Level after Irradiation

Jun Ma, Deping Han, Mei Zhang, Chun Chen, Bingrong Zhang, Zhenhuan Zhang, Xiaohui Wang, Shanmin Yang, Yansong Guo, Paul Okunieff, and Lurong Zhang

23. Fibroblast Growth Factor-peptide Promotes Bone Marrow Recovery after Irradiation

Jun Ma, Yanqian Hou, Deping Han, Mei Zhang, Chun Chen, Bingrong Zhang, Zhenhuan Zhang, Xiaohui Wang, Shanmin Yang, Yansong Guo, Paul Okunieff, and Lurong Zhang

24. Dynamic Two-Photon Imaging of Cerebral Microcirculation Using Fluorescently Labeled Red Blood Cells and Plasma

Kazuto Masamoto, Hiroshi Kawaguchi, Hiroshi Ito, and Iwao Kanno

25. The Effect of Basic Assumptions on the Tissue Oxygen Saturation Value of Near Infrared Spectroscopy

Andreas Jaakko Metz, Martin Biallas, Carmen Jenny, Thomas Muehlemann, and Martin Wolf

26. The Effect of Sudden Depressurization on Pilots at Cruising Altitude

Thomas Muehlemann, Lisa Holper, Juergen Wenzel, Martin Wittkowski, and Martin Wolf

27. Hypoxia in the Diabetic Kidney is Independent of Advanced Glycation End-products

Lina Nordquist, Per Liss, Angelica Fasching, Peter Hansell, and Fredrik Palm

28. Tumor Oxygen Measurements and Personalized Medicine

Paul Okunieff, Walter O'Dell, Mei Zhang, Lurong Zhang, and David Maguire

29. Wavelet Cross-Correlation to Investigate Regional Variations in Cerebral Oxygenation in Infants supported on Extra-Corporeal Membrane Oxygenation

Maria Papademetriou, Ilias Tachtsidis, Martin J. Elliott, Aparna Hoskote, and Clare E. Elwell

30. Association of the Red Cell Distribution Width with Red Blood Cell Deformability

Kushang V. Patel, Joy G. Mohanty, Bindu Kanapuru, Charles Hesdorffer, William B. Ershler, and Joseph M. Rifkind

31. Kidney Function after In Vivo Gene Silencing of Uncoupling Protein-2 in Streptozotocin-induced Diabetic Rats

Malou Friederich Persson, William J. Welch, Christopher S. Wilcox, and Fredrik Palm

32. Adenosine A2 Receptor-mediated Regulation of Renal Hemodynamics and Glomerular Filtration Rate is Abolished in Diabetes

Patrik Persson, Peter Hansell, and Fredrik Palm

33. Can Mitochondrial Cytochrome Oxidase Mediate Hypoxic Vasodilation via Nitric Oxide Metabolism?

Zimei Rong, Murad Banaji, Tracy Moroz, and Chris E. Cooper

34. Effects of Occlusal Disharmony on Working Memory Performance and Prefrontal Cortex Activity Induced by Working Memory Tasks Measured by NIRS

Kaoru Sakatani, Takeo Tsujii, Teruyasu Hirayama, Youichi Katayama, Tomotaka Takeda, Ai Amemiya, and Keiichi Ishigami

35. Biological Maintenance of Distal Vein Arterialization

Tadahiro Sasajima, and Tomiyasu Koyama

36. Bayesian STAI Anxiety Index Predictions Based on Prefrontal Cortex NIRS Data for the Resting State

Masakaze Sato, Wakana Ishikawa, Tomohiko Suzuki, Takashi Matsumoto, Takeo Tsujii, and Kaoru Sakatani

37. The Effect of Venous and Arterial Occlusion of the Arm on Changes in Tissue Blood Flow/Volume, Oxygenation and Ultra-weak Photon Emission

Felix Scholkmann, Olaf Schraa, Roeland van Wijk, and Martin Wolf

38. Metabolic Network Analysis of DB1 Melanoma Cells: How much Energy is Derived from Aerobic Glycolysis?

A.A. Shestov, A. Mancuso, D. B. Leeper, and J. D. Glickson

39. Muscle Oxygen Saturation Heterogeneity among Leg Muscles during Ramp Exercise

Shun Takagi, Ryotaro Kime, Masatsugu Niwayama, Norio Murase, and Toshihito Katsumura

40. PET-imaging of the Impact of Extracellular pH and MAP Kinases on the p-glycoprotein (Pgp) Activity

Oliver Thews, Wolfgang Dillenburg, Frank Roesch, and Marco Fellner

41. Meconium and Transitional Stools May Cause Interference with Near-Infrared Spectroscopy Measurements of Intestinal Oxygen Saturation in Preterm Infants

Alecia Thompson, Paul Benni, Sara Seyhan, and Richard Ehrenkranz

42. Acute Effects of Physical Exercise on Prefrontal Cortex Activity in Older Adults: A Functional Near-Infrared Spectroscopy Study

Takeo Tsujii, Kazutoshi Komatsu, and Kaoru Sakatani

43. Blood Flow and Oxygenation Status of Prostate Cancers

Peter Vaupel, and Debra K. Kelleher

44. Targeted Delivery of VEGF to Treat Myocardial Infarction

Bin Wang, Rabe'e Cheheltani, Jenna Rosano, Deborah L. Crabbe, and Mohammad F. Kiani

45. Magnetic Nanoparticles and Thermally-Responsive Polymer for Targeted Hyperthermia and Sustained Anti-Cancer Drug Delivery

Sarah Y. Wang, Michelle C. Liu, and Kyung A. Kang

46. NIR Fluorophore-Hollow Gold Nanosphere Complex for Cancer Enzyme Triggered Detection and Hyperthermia

Jianting Wang, Damon Wheeler, Jin Z. Zhang, Samuel Achilefu, and Kyung A. Kang

47. Renal Oxygenation and Function of the Rat Kidney: Effects of Inspired Oxygen and Preglomerular Oxygen Shunting

Christopher S. Wilcox, Fredrik Palm, and William J. Welch

48. Alteration of the Inflammatory Molecule Network after Irradiation of Soft Tissue

Zhenyu Xiao, Shanmin Yang, Ying Su, Wei Wang, Hengshan Zhang, Mei Zhang, Kunzhong Zhang, Yeping Tian, Yongbing Cao, Liangjie Yin, Lurong Zhang, and Paul Okunieff

49. Imaging the Redox States of Human Breast Cancer Core Biopsies

H. N. Xu, J. Tchou, B. Chance, and L. Z. Li

50. Early Life Hypoxic or Hypoxic/hypercapnic Stress Alters Acute Ventilatory Sensitivity in Adult Mice

Kui Xu, Solomon Raju Bhupanapadu Sunkesula, Pengjing Huang, Constantinos P. Tsipis, Thomas Radford, Gerald Babcock, Walter F. Boron, and Joseph C. LaManna

51. 3D Analysis of Intracortical Microvasculature during Chronic Hypoxia in Mouse Brain

Kouichi Yoshihara, Hiroyuki Takuwa, Iwao Kanno, Shinpei Okawa, Yukio Yamada, and Kazuto Masamoto

52. Contribution of Brain Glucose and Ketone Bodies to Oxidative Metabolism

Yifan Zhang, Youzhi Kuang, Joseph C. LaManna, and Michelle A. Puchowicz

53. Alteration of Circulating Mitochondrial DNA Concentration after Irradiation

Mei Zhang, Bingrong Zhang, Yansong Guo, Lei Zhang, Shanmin Yang, Liangjie Yin, Sadasivan Vidyasagar, David Maguire, Steve Swarts, Zhenhuan Zhang, Amy Zhang, Lurong Zhang, and Paul Okunieff