Main description:

This handbook details advances in pancreatic cancer research that have a profound and lasting impact on the field. It features the work of authors who are the very best in their respective fields and will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field.

Feature:

The only Major Reference Work devoted entirely to pancreatic cancer

The contributing authors to this book are the very best in their respective fields

Will have widespread appeal among clinicians, pathologists, and basic scientists who are now struggling to understand this complex and rapidly growing field

Contents:

Section One: The Nature of Pancreatic Cancer

1. Epidemiology: world overview, risk factors, prospects for prevention








2. Development and structure of pancreas








3. Pathologic classification and biological behaviour of pancreatic neoplasia








4. Developmental molecular biology of the pancreas








5. Molecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)








6. Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancer








7. Molecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, Neurofibromatosis








8. Sporadic neuroendocrine pancreatic tumours








9. Molecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancer








10. Miscellaneous non-pancreatic non-endocrine tumours








11. Novel molecular relationships between chronic pancreatitis and cancer








12. Pancreatic cancer stem cells








13. Cell cycle control: signalling pathways in pancreatic pathogenesis








14. Apoptosis: signalling pathways in pancreatic pathogenesis








15. EGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK








16. Hedgehog: signalling pathways in pancreatic pathogenesis








17. Smad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesis








18. Notch signalling in pancreatic morphogenesis and pancreatic cancer








19. Molecular characterization of pancreatic cell lines








20. Mouse models of exocrine pancreatic cancer








21. Principles and applications of microarray gene expression in pancreatic cancer








22. Principles and applications of proteomics in pancreatic cancer








23. Tumour-stromal interaction: invasion and metastases








24. Genetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromes








25. Inherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1







 




Section Two: Clinical Management of Pancreatic Cancer









26. Clinical decision making in pancreatic cancer








27. Paraneoplastic syndromes








28. Diagnostic and therapeutic response markers








29. CT and fusion PET-CT Diagnosis, staging, and follow-up








30. MRI and MRCP: diagnosis and staging of pancreatic cancer








31. EUS Diagnosis and staging








32. Laparoscopy and laparoscopic ultrasound: diagnosis and staging








33. Overview of palliative management for pancreatic cancer








34. Endoscopy.








35. Interventional radiology








36. Role of palliative surgery in advanced pancreatic cancer








37. Chemotherapy for advanced pancreatic cancer








38. Developments in chemoradiation in advanced pancreatic cancer








39. Surgical resection for pancreatic cancer








40. Role of venous resection in pancreatic cancer surgery








41. Pathological reporting and staging following resection








42. Japanese Pancreas Society staging for pancreatic cancer








43. Adjuvant chemotherapy in pancreatic cancer








44. Case for adjuvant chemoradiation therapy for pancreatic cancer








45. Case for neoadjuvant treatment in pancreatic cancer








46. Borderline resectable disease








47. Management of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasms








48. Laparoscopic surgery for pancreatic neoplasm








49. Modern Japanese approach to pancreas cancer







 




Section Three: New Directions









50. Development of novel biomarkers








51. Inherited genetics of pancreatic cancer and secondary screening








52. Gene therapy for pancreatic cancer








53. Vaccine therapy and immunotherapy








54. Emerging targets in pancreatic cancer