Main description:

This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.

Contents:

The History of Nerve Repair.- Part I: The Peripheral Nerve Repair Environment. - Blood Supply and Microcirculation of the Peripheral Nerve.- The Immune Response and Implications for Nerve Repair.- Autonomic Nervous System Repair and Regeneration.- Part II: Models and Evaluation of Peripheral Nerve Regeneration.- Appropriate Animal Models for Translational Nerve Research.- Basic Nerve Histology and Histological Analyses Following Peripheral Nerve Repair and Regeneration.- Mathematical Modelling for Nerve Repair Research.- Part III: Biomaterials for Peripheral Nerve Regeneration.- Biomaterials and Scaffolds for Repair of the Peripheral Nervous System.- Fibrin in Nerve Tissue Engineering.- Silk Biomaterials in Peripheral Nerve Tissue Engineering.- Collagen Biomaterials for Nerve Tissue Engineering.- Part IV: Therapeutic Options for Peripheral Nerve Regeneration.- Schwann Cells in Nerve Repair and Regeneration.- Therapeutic Cells and Stem Cells for Nerve Regeneration.- Extracellular Vesicles for Nerve Regeneration.- Drug Therapies for Peripheral Nerve Injuries.- Part V: Clinical Aspects. -Surgical Techniques in Nerve Repair.- Clinical Outcome Measures Following Peripheral Nerve Repair.- Regenerative Therapies for Acquired Axonal Neuropathies.- Rehabilitation of Nerve Injuries.