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MORE ABOUT THIS BOOK
Main description:
A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.
Contents:
Part I. Platelet Physiology
Platelet Physiology
Martin Quinn
Platelet Integrins and Signaling
Karlheinz Peter
Platelet Adhesion
Brian Savage and Zaverio M. Ruggeri
Structure-Function of the Platelet Cytoskeleton
Elaine L. Bearer
Platelets and Inflammation
Meinrad Gawaz
Platelet Signal-Dependent Protein Synthesis
Stephan Lindemann, Thomas M. McIntyre, Stephen M. Prescott, Guy A. Zimmerman, and Andrew S. Weyrich
Phosphoproteomics of Human Platelets
Katrin Marcus and Helmut E. Meyer
Part II. Assessing Platelet Function
Platelet Function Studies
Dermot Cox
Platelet Function Under Flow
Jose A. Lopez, Ian del Conde, and Jing-Fei Dong
Pharmacodynamics of GPIIb-IIIa Receptor Blockade
Lisa K. Jennings and Melanie M. White
Prostanoid Generation in Platelet Function: Assessment and Clinical Relevance
Bianca Rocca and Carlo Patrono
Platelets and Prothrombin
Michael Kalafatis, Emil Negrescu, Tatiana Byzova, and Edward F. Plow
Markers of Platelet Activation and Granule Secretion
Alan D. Michelson and Mark I. Furman
Genomic and Proteomic Analysis of Platelets: Clinical Applications
Andrew Maree and James McRedmond
Part III. Clinical Applications
Antiplatelet Agents
Jacqueline Saw and David J. Moliterno
Assessing Platelet Function in Clinical Trials
Neal Kleiman
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 408
Weight: 697g
Availability: Available
Subcategories: Cardiovascular Medicine
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