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Pneumococcal Vaccines
The Impact of Conjugate Vaccine
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Main description:

Presents the latest findings on the effects of pneumococcal conjugate vaccine.

Describes the development of the vaccines, their remarkable impact on respiratory and other pneumococcal infections, and the vaccines' wider impact on public health.
Includes chapters on epidemiology, immunologic mechanisms, conjugation methods, antibiotic resistance, PCV immunogenicity in healthy and high-risk individuals, otitis media, and direct and indirect protective effects.
Summarizes the current knowledge on pneumococcal vaccines with particular emphasis on the years after the introduction of the conjugate vaccine for professionals in academia, public health, government, or industry.

This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.


Contents:

Table of Contents

Dedication: Robert Austrian, M.D., Jeffrey N. Weiser, M.D.

I. HISTORY

1 The History of Pneumococcal Disease, Barry M. Gray and Daniel M. Musher

2 History of Pneumococcal Immunization, P. Helena Makela and Jay C. Butler

II. BIOLOGICAL BASIS

3 Genetics, Biosynthesis, and Chemistry of Pneumococcal Capsular Polysaccharides, Janet Yother, Stephen D. Bentley, and John P. Hennessey, Jr.

4 Animal Models of Invasive Pneumococcal Disease, David E. Briles, Susan K. Hollingshead, and Ingileif Jonsdottir

5 Animal Models of Pneumococcal Colonization, Richard Malley and Jeffrey N. Weiser

6 The Immunobiology of Polysaccharide and Conjugate Vaccines, David Goldblatt, Tracy Assari, and Clifford Snapper

7 Interactions of Streptococcus pneumoniae with Complement Proteins, Margaret K. Hostetter

III. CLINICAL DISEASE AND EPIDEMIOLOGY

8 Epidemiology, Diagnosis, and Treatment of Serious Pneumococcal Infections in Children, Shabir A. Madhi and Stephen I. Pelton

9 Pneumococcal Pneumonia in Adults: Epidemiology, Clinical Features, Diagnosis, and Therapy, Jeffrey B. Rubins, David Boulware, and Edward N. Janoff

10 Pneumococcal Serotype Epidemiology, William P. Hausdorff, Angela B. Brueggemann, Jill G. Hackell, and J. Anthony G. Scott

IV. MANUFACTURING AND PRODUCT RELEASE ISSUES

11 Conjugation Chemistry, Andrew Lees, Velupillai Puvanesarajah, and Carl E. Frasch

12 Pneumococcal Vaccines: Manufacture and Quality Control for Product Release, Milan S. Blake

13 Licensing of Pneumococcal Conjugate Vaccines for Children and Adults: Regulatory Perspective from the European Medicines Agency and the U.S. Food and Drug Administration, Marion F. Gruber, Douglas Pratt, and Manfred Haase

V. IMMUNOGENICITY

14 Quantitation of Anti-Pneumococcal Capsular Antibody in Ligand-Binding Assays, Dace V. Madore, Sally A. Quataert, and Merja Vakevainen

15 Functional Assays for Pneumococcal Antibody, Moon H. Nahm and Sandra Romero-Steiner

16 Immunogenicity and Reactogenicity of Pneumococcal Conjugate Vaccines in Infants and Children, Helena Kayhty, Stephen Lockhart, and Lode Schuerman

17 Immunogenicity and Safety in Adults, Lisa A. Jackson and George R. Siber

18 Immunogenicity in High-Risk and Immunocompromised Children and Adults, Neil French, Sharon Nachman, and Stephen I. Pelton

VI. EFFICACY AND SAFETY

19 Nasopharyngeal Carriage, Katherine L. O'Brien, Ron Dagan, and P. Helena Makela

20 Acute Otitis Media and Its Sequelae, Terhi Kilpi and Lode Schuerman

21 Meta-Analysis of the Efficacy of Conjugate Vaccines against Invasive Pneumococcal Disease, Keith P. Klugman, Felicity Cutts, Richard A. Adegbola, Steven Black, Shabir A. Madhi, Katherine L. O'Brien, Mathuram Santosham, Henry Shinefield, and Jonathan A. C. Sterne

22 Efficacy and Safety of Conjugate Pneumococcal Vaccine in the Prevention of Pneumonia, Shabir A. Madhi and Keith P. Klugman

23 Establishing Immune Correlates of Protection, Robert C. Kohberger, Jukka Jokinen, and George R. Siber

VII. PUBLIC HEALTH IMPACT

24 Direct and Indirect Effectiveness and Safety of Pneumococcal Conjugate Vaccine in Practice, Cynthia G. Whitney and Matthew R. Moore

25 Impact of Conjugate Pneumococcal Vaccine on Antibiotic Resistance, Ron Dagan and Keith P. Klugman

26 Pharmacoeconomics of Pneumococcal Conjugate Vaccines, Anushua Sinha and G. Thomas Ray

27 Opportunities and Challenges for Pneumococcal Conjugate Vaccines in Low- and Middle-Income Countries, Orin S. Levine and Brian Greenwood

VIII. WHERE NEXT

28 Protein Vaccines, James C. Paton and John W. Boslego

Conclusions, George R. Siber, Keith P. Klugman, and P. Helena Makela


PRODUCT DETAILS

ISBN-13: 9781555814083
Publisher: American Society for Microbiology
Publication date: February, 2008
Pages: 520
Weight: 1436g
Availability: Not available (reason unspecified)
Subcategories: Neurology

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