Main description:

Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles.

Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles - such as mucosal and transdermal - and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.

Contents:

Part A: Synthesis and characterization of polymeric micelles for drug delivery 1. Polymeric micelles: pre cis for past, present, and future 2. Various polymers in the development of polymeric micelles 3. Solubility enhancement and drug release mechanism of polymeric micelles 4. Polymeric micellar nanomedicine for enhanced permeability and retention effect 5. Polymeric micelles for oral drug delivery 6. Polymeric micellar nanocarriers: topical treatment of inflammatory diseases

Part B: Application of polymeric micelles in drug delivery 7. Polymeric micelles in dermal and transdermal drug delivery 8. Polymeric micelles as delivery systems for anticancer immunotherapy 9. Polymeric micelles for drug delivery in oncology 10. Surface engineering of polymeric micelles for imparting multifunctionality 11. Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell

Part C: Stimuli-responsive polymeric micelles for drug delivery 12. pH-responsive polymeric micelles for drug delivery 13. Enzyme-responsive polymeric micelles for drug delivery applications 14. Light- and temperature-responsive polymeric micelles for drug delivery 15. Exogenous stimuli 16. Dual-responsive polymeric micelles for drug delivery

Part D: Recent advances in polymeric micelles 17. Polymeric micelles for drug codelivery 18. Nose-to-brain delivery 19. The application of a drug 20. Polymeric micelles with cleavable links for drug delivery 21. Block copolymer micelles as long-circulating drug delivery vehicles 22. Triblock polymeric micelles as an emerging nanocarrier for drug delivery

Part E: Environmental and regulatory aspects 23. Biological toxicity and environmental hazards associated with polymeric micelles 24. Clinical translation of polymeric micelles into market 25. Regulatory pathways and prospects for polymeric micelles