Main description:

This book serves as a guide to the pulmonary and critical care complications of hematopoietic stem cell transplantation (HSCT). HSCT is an important therapeutic modality for a variety of malignant and non-malignant conditions. The outcomes of these patients have been improving and the number of HSCT cases is increasing around the world. These patients, however, continue to have post-transplant complications related to conditioning regimens and graft vs. host disease. Pulmonary complications following HSCT remain a major cause of morbidity and mortality in this patient population.

The book begins with an overview of HSCT and graft vs. host disease. Chapters then cover particular complications, including immunological changes in lungs, diffuse alveolar hemorrhage, bronchiolitis obliterans and pulmonary fibrosis. Other complications, including neurologic, renal, gastrointestinal, and cardiac, are covered. Chapters are comprehensive and consistent with each defining the scope of the complication, epidemiology, risk factors, diagnostic approach, management, outcome and predictors of outcome, and future directions. The book provides insight as well on matters that arise during the care of HSCT patients such as provider burnout, nursing care, intensive care unit organization, nutritional support, and pulmonary and physical rehabilitation.

This is an ideal guide for pulmonologists, critical care physicians, transplant specialists, oncologists, and relevant trainees caring for patients who have undergone HSCT.

Contents:

HSCT- overview- types, indications, epidemiology, outcomesGraft vs Host Disease- manifestations and managementImmunological changes in lungs following HSCTSpectrum of pulmonary complications following HSCTPre-transplant pulmonary evaluationDiagnostic evaluation of pulmonary diseases following HSCTChest radiology in HSCTBacterial respiratory infectionsAspergillosisOther fungal respiratory infectionsCMV pneumoniaRespiratory viral infectionsEmerging infectionsDiffuse alveolar haemorrhageEngraftment SyndromeIdiopathic pneumonia syndromeBronchiolitis obliterans syndromePulmonary fibrosisOther non-infectious pulmonary complicationsCo-morbid pulmonary diseases in HSCT patientPulmonary rehabilitation and HSCTLung transplant for HSCT patientCritical care outcomes of HSCT patientRespiratory support of critically ill HSCT patient- MV, NIV, HFNCCardiac considerations in critically ill HSCT patientRenal considerations in critically ill HSCTGI and hepatic considerations in critically ill HSCT patientNeurologic considerations in critically ill HSCT patientHematologic considerations in critically ill HSCT patientCritical care nursing of HSCT patientSupportive care and HSCT patientCoordinating care of HSCT with pulmonary and critical care illness-outpatient/BMT-ICU care units/ multidisciplinary ICU rounds/ telemedicine.