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Main description:
Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.
Contents:
RNA Polymerases and Transcription Factors of Trypanosomes.- SL RNA biogenesis in kinetoplastids: a long and winding road.- Pre-mRNA splicing in Trypanosoma brucei: factors, mechanisms, and regulation.- mRNA turnover in trypanosomes.- tRNA biogenesis and processing.- rRNA biogenesis in trypanosomes.- RNA Editing in African Trypanosomes - a User's Guide.- The RNA Interference Pathway in Trypanosoma brucei.- Translation in trypanosomatids.- Mitochondrial translation in trypanosomatids.- RNA-Seq analysis of the transcriptome of Trypanosoma brucei.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: July, 2014
Pages: 274
Weight: 433g
Availability: Available
Subcategories: Biochemistry, Genetics, Microbiology
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