Main description:

This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology.

In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung's innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease.

To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.

Contents:

1- Sex differences in respiratory physiology - V. Sathish

2- Sex steroids and their influence in lung disease across the lifespan - F. Gomez Real

3- Neonatal lung disease: mechanisms driving sex differences - K. Lingappan

4- Sex differences in the pediatric lung: implications for lung disease - E. Arteaga-Solis

5- Lung diseases affecting women: genetic, anatomical, and physiological influences. - M. Hardin

6- Lung diseases affecting men: genetic, anatomical, and physiological influences. - R Jain

7- Sex differences in susceptibility to rare lung diseases - C. McCarthy

8- Relationships between respiratory and the male vs. female endocrine systems - M. Lencu

9- The lungs and the environment: sex differences in susceptibility to environmental exposures. - P. Silveyra

10- Sex specific effects of tobacco exposure - S. McKee

11- Sex differences in chronic obstructive pulmonary disease - D. DeMeo

12- Sex differences in lung innate immunity: implications for host responses - N. Heller

13- Sex specific lung adaptive immunity in chronic lung disease - D. Newcomb

14- Sex differences in airway remodeling - M. Stampfli

15- Sex differences in respiratory infection - S. Klein

16- The lung microgenderome - A. Morris

17- Sex differences in smoke inhalation lung injury - R. Maile

18- Lung cancer in men and women: physiological aspects - C. Dressler

19- Sex-specific effects in pulmonary vascular disease - T. Lahm

20- Sex differences in pulmonary arterial hypertension - S. Erzurum

21- Systems biology approaches to understand sex differences in lung disease - A. Arnold

22- Sex differences in circadian and sleep biology: influences on lung health - F. Duffy

23- Sex-specific lung disease therapeutics: are we there yet? - P. Silveyra