Main description:

This special topic issue on 'Sexual Differentiation of Vertebrate Reproductive Organs' continues and complements the story that was first taken up in a previously published issue dealing with the 'Control of Gonadal Development'. This new publication focuses on the transition from sex determination to sexual differentiation. Due to the fact that most work has been conducted on mice, it is not surprising that many generalisations have developed, even though only some of these apply to all mammals. This special topic issue aims to shed some light on these generalisations. It covers the different mechanisms of sex determination in mice, reptiles and birds. Further insights are provided on the somatic lineages, gonadal differentiation and disorders of sexual development in mammals, fishes and humans. The last few chapters focus on the development and molecular control of the duct system and the development of external genitalia in mammals and also discuss how these evolved in reptiles.
This publication is recommended for anyone who would like to know more about what directs male and female sexual dimorphisms at molecular, cellular, developmental, physiological and endocrinological levels.