Main description:

Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics.

Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors.

Contents:

Related titles
List of contributors
Woodhead Publishing Series in Biomaterials
Introduction
Part One. Switchable and responsive materials and surfaces

1. Thermo-responsive polymers: structure and design of smart materials

1.1. Introduction
1.2. Thermo-responsive polymers and their characteristics
1.3. Types of thermo-responsive polymers
1.4. Physical forms of switchable materials and their applications
1.5. Summary

2. Environmentally responsive polyelectrolytes and zwitterionic polymers

2.1. Introduction
2.2. Monomer subunits and polymerization approaches
2.3. General solution properties
2.4. Stimuli-induced changes and their applications
2.5. Future trends
2.6. Sources of further information

3. Peptide-based switchable and responsive surfaces

3.1. Introduction
3.2. Preparation of peptide surfaces
3.3. Responsive peptide surfaces
3.4. Peptides attached to responsive surfaces
3.5. Protein surfaces
3.6. Physical properties and characterisation
3.7. Emerging applications
3.8. Future trends

4. Photonic sensitive switchable materials

4.1. Introduction
4.2. Photonic sensitive switchable materials
4.3. Potential applications
4.4. Conclusions and future trends

5. Responsive polymer brushes for biomedical applications

5.1. Introduction
5.2. Brush architecture
5.3. Types of responsive polymer brushes
5.4. Biomedical applications
5.5. Summary and future trends

6. Preparation and analysis of switchable copolymers for biomedical application

6.1. Introduction
6.2. Switchable copolymer coatings
6.3. Advanced analytical techniques
6.4. Future trends
6.5. Sources of further information

Part Two. Biological interactions and biomedical applications of switchable surfaces

7. Interaction of switchable biomaterials surfaces with proteins

7.1. Introduction
7.2. Protein adsorption on surfaces
7.3. Protein adsorption on thermo-responsive surfaces
7.4. Protein adsorption on pH and/or ionic strength-responsive surfaces
7.5. Protein adsorption on other responsive surfaces
7.6. Synergistic effect of surface chemistry and nanostructures on protein adsorption
7.7. Aspects for future research

8. Interaction of responsive/switchable surfaces with cells

8.1. Introduction
8.2. Controlling stem cell behavior
8.3. Interfacial properties
8.4. Physical behavior
8.5. Future trends

9. Temperature-responsive polymers for cell culture and tissue engineering applications

9.1. Introduction
9.2. Methods for preparing temperature-responsive cell culture surfaces (TRCSs) and their characteristics
9.3. Cell sheet-based regenerative medicine
9.4. Future application of temperature-responsive cell culture surface to support and promote regenerative medicine field

10. Stimuli-sensitive polymers for drug delivery and diagnostic systems interacting with biosurfaces

10.1. Introduction
10.2. Polymers sensitive to body's internal stimuli
10.3. Polymers sensitive to the body's external stimuli
10.4. Future trends

11. Application of responsive polymers in implantable medical devices and biosensors

11.1. Introduction
11.2. Biocompatibility of medical devices and responsive polymers
11.3. Cardiovascular devices
11.4. Drug delivery/infection control coatings and devices
11.5. Surgical devices
11.6. Dental and orthopedic devices
11.7. Ophthalmic devices
11.8. Respiratory devices
11.9. Gastrointestinal devices
11.10. Urogenital devices/urinary devices
11.11. Insulin delivery devices for diabetes management
11.12. Biosensors
11.13. Summary

Index