Main description:

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington's disease, Epilepsy, Parkinson's disease and Alzheimer's disease.

Contents:

Preface (The Editors)

Historical Overview (Burnstock G.1, & Abbracchio MP.2; 1University College Medical School, London, UK; 2 University of Milan, Italy)

Molecular Structure, Distribution and Signal Transduction (Linden J.; Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA)

Thermodynamic Analysis of ARs (Borea PA. & Vincenzi F.; Department of Medical Sciences, University of Ferrara, Italy)

Medicinal Chemistry of A1 ARs (Scammels PJ., Medicinal Chemistry & Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Australia)

Medicinal Chemistry of A2A ARs (Baraldi PG.1 & Jacobson KA.2; 1 Department of Pharmaceutical Sciences, University of Ferrara, Italy; 2 National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MA, USA)

Medicinal Chemistry of A2B ARs (Muller C., Pharma Center Bonn, Pharmaceutical Institute, University of Bonn, Germany)

Medicinal Chemistry of A3 ARs (Jacobson KA.1 & Baraldi PG.2; 1 National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MA, USA; 2 Department of Pharmaceutical Sciences, University of Ferrara, Italy)

Adenosine Receptors in Neuroinflammation (Borea PA., Gessi S., Merighi S.; Department of Medical Sciences, University of Ferrara, Italy)

Parkinson's disease (Franco R., University of Barcelona, Barcelona, Spain)

Alzheimer's disease (Cunha RA., University of Coimbra, Coimbra, Portugal)

Huntington's disease (Cattaneo E., Department of BioSciences and Centre for Stem Cell Research, University of Milan, Italy)

Amyotrophic Lateral Sclerosis (Popoli P., Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy).

Neuropsychiatric Disorders (Chen JF., Department of Neurology, Boston University School of Medicine, Boston, MA, USA)

Epilepsy (Ribeiro JA. & Sebastiao AM., Institute of Pharmacology and Neurosciences, Faculty of Medicine, and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal)

Cerebral Ischemia (Pedata F., Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy)

Pain (Salvemini D., Department of Pharmacology and Physiology, Saint Louis Universit

y School of Medicine , Missouri, USA)

Cardiovascular System (Schrader J., Department of Molecular Cardiology, Heinrich Heine University Dusseldorf, Germany)

Pulmonary System (Barnes PJ., Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London)

Renal System (Schnermann J., National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MA, USA)

Immune & Inflammatory System (Cronstein BN., New York University School of Medicine, NY - USA;

Obesity (Dhalla AK., Gilead Sciences Incorporated, Fremont, CA, USA)

Cancer (Fishman P., Can Fite Biopharma, Israel)

Adenosine and Pulsed Electromagnetic Fields (Borea PA. & Varani K., Department of Medical Sciences, University of Ferrara, Italy)

Current and Future Trends in Drug Discovery (Fredholm B.B., Department of Physiology and Pharmacology, Karolinska Institutet, Sweden)