Main description:

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases.

Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome.

Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Contents:

1.Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans

Gabriela Toomer, Huachen Gan, Joanna Sztuba-Solinska

2. Evolving Roles of Long Noncoding RNAs

K. Lakshmi Narayanan, Xizi Wu, Haichao Wei and Jiaqian Wu

3.Biogenesis and Function of the Noncoding Isoform-Type LncRNAs

Yasuhiko Kato and Hajime Watanabe

4. Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization

Raphael Severino Bonadio, Enrico Alessio, Stefano Cagnin

5. Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes

Sonam Dhamija and Manoj B. Menon

6. Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2

Nicholas Delihas

7. Long Non-Coding RNAs and Cancer Cells' Drug Resistance: an Unexpected Connection

Perla Pucci, Erik Venalainen, Wallace Yuen, David Roig Carles, Yuzhuo Wang, Francesco Crea

8. Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma

Johanna K. DiStefano and Caecilia Sukowati

9. Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers

Bernadette Neve, Nicolas Jonckheere, Audrey Vincent and Isabelle Van Seuningen

10. LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer

Yuichi Mitobe, Kazuhiro Ikeda, Kuniko Horie-Inoue and Satoshi Inoue

11. Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer

Marianna Aprile, George Calin, Amelia Cimmino and Valerio Costa

12. Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art

Panagiotis Paliogiannis, Valentina Scano, Arduino Aleksander Mangoni, Antonio Cossu, Giuseppe Palmieri

13. Long Non-Coding RNAs in Cardiovascular Diseases

Laura Schoppe, Tim Meinecke, Patrick Hofmann, Ulrich Laufs, Jes-Niels Boeckel

14. Long Non-Coding RNAs in Cardiovascular Development and Diseases

Jiali Deng, Mengying Guo, Junjie Xiao

15. Long Noncoding RNAs as Players in Breast Tumorigenesis

Cyrinne Achour and Francesca Aguilo

16. Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders

Yuuka Muraoka, Masamitsu Yamaguchi

17. Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders

Keisuke Hitachi and Kunihiro Tsuchida

18. Long Noncoding RNAs in Substance Use Disorders

Changhai Tian and Guoku Hu

19. The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm

Saumik Biswas and Subrata Chakrabarti

20. Long Non-Coding RNAs in Diabetes and -cell Regulation

Simranjeet Kaur, Caroline Frorup, Verena Hirschberg Jensen, Aashiq H. Mirza, Joana Mendes Lopes de Melo, Reza Yarani, Anne Julie Overgaard, Joachim Storling, Flemming Pociot