Main description:

In dedication of Professor Rose and Professor Mackay who both passed away in 2020. A global group on experts in the field updated this Seventh Edition of The Autoimmune Diseases.

The Rose-Mackay Textbook of Autoimmune Diseases, is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.

The new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.

Contents:

Section 1: Immunologic Basis of Autoimmunity 1. Prelude: Historical introduction to autoimmunity and autoimmune disease 2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 3. General Features of Autoimmune Diseases (same title new contributor, new content) 4. Antigen Presentation, Dendritic Cells, and Autoimmunity 5. T cells and their subsets 6. Role of Th1 Th2 Th17 Cells in Autoimmunity 7. Tolerance and Autoimmunity: T Cells 8. Regulatory T Cells 9. B Cells and Autoimmunity 10. Immunological memory T cells 11. Immunological memory B cells 12. Apoptotic Cells as a Source of Autoantigens 13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes 14. Functional Effects of Autoantibodies 15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes 17. HLA Genetics and Autoimmunity 18. Non HLA Genetics 19. AIRE related Autoimmunity 20. Immune Deficiencies and Autoimmunity 21. Infections and Autoimmunity 22. Noninfectious Environmental Agents and Autoimmunity 23. Sex, Pregnancy and Autoimmunity 24. Animal Models of Autoimmune Disease

Section 2: Multisystem Diseases 25. Systemic Lupus Erythematosus 26. Systemic Sclerosis, Scleroderma 27. Antiphospholipid Syndrom 28. Sjogren Syndrome 29. Rheumatoid Arthritis 30. Spondyloarthritis and Chronic Idiopathic Arthropathies 31. Myositis 32. Thyroid Disease 33. Type 1 Diabetes 34. Adrenalitis 35. Polyendocrine Syndromes 36. Gastritis and Pernicious Anemia 37. Hypophysitis 38. Hemolytic Anemia 39. Thrombocytopenic Purpura 40. Neutropenia 41. Aplastic Anemia 42. Clotting Disorders 43. Multiple Sclerosis 44. Peripheral Neuropathy 45. Myasthenia Gravis 46. Ocular Disease 47. Inner Ear Disease 48. Celiac Disease 49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease 50. Chronic Hepatitis 51. Primary Billiary Cirrhosis 52. Primary Sclerosing Cholangitis 53. Pancreatitis 54. Bullous Skin Diseases: Pemphigus and Pemphigoid 55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria 56. Kidney Disease: Goodpasture's Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis 57. Orchitis and Male Infertility 58. Oophoritis 59. Rheumatic Heart Disease 60. Myocarditis and Dilated Cardiomyopathy 61. Necrotizing Arteritis and Small Vessel Vasculitis 62. Large and Medium Vessel Vasculitides 63. Autoimmune Disorders of the Lung 64. Paraneoplastic Diseases 65. Antibody-Associated Neurological Diseases 66. Autoinflammatory and other Related Diseases 67. Autoinflammatory diseases and autoimmune responses to tumors 68. COVID

Section 3: Diagnosis, Prevention, and Therapy 69. Autoantibody Assays, Testing, and Standardization 70. Prediction of Autoimmune Disease 71. Emerging Therapies for Autoimmune Diseases 72. Postlude