Main description:

This book reviews the role of trace elements in brain development, function, metabolism, and neurodegenerative disorders. It explores the molecular mechanisms of the effects of trace elements on metabolic pathways, mitochondrial nutrients, neurodegeneration, Central Nervous System (CNS) disorders, cell signaling, and neuronal functions. The book also discusses transport mechanisms of trace elements within CNS and their impact on neurotransmitter biology. Further, it examines the deleterious effects due to dyshomeostasis of trace elements in the central nervous system (CNS), resulting in damage to neurons and glial cells through the generation of reactive oxygen species and oxidative stress turn leading to neurodegeneration and neurological dysfunction. The book also explores the putative role of trace element deficiency in psychiatric disorders, including depression, and the imbalance of trace elements on neuronal genomic stability.

Contents:

Chapter 1_Overview of Trace Elements. -Chapter 2_Trace elements and brain development. -Chapter 3_Trace elements and brain function. -Chapter 4_Trace elements and oxidative stress. -Chapter 5_Trace elements and neurotransmitters. -Chapter 6_Homeostasis of trace elements in the brain. -Chapter 7_ Putative role of trace elements deficiency in psychiatric disorders including depression. -Chapter 8_Trace elements and neuro-developmental disorders. -Chapter 9_Trace elements and Parkinson's disease. -Chapter 10_Trace elements and Alzheimer's disease. -Chapter 11_Trace elements and multiple sclerosis. -Chapter 12_Trace elements and epilepsy. -Chapter 13_Trace elements and sleep disorders. -Chapter 14_Trace elements and Subarachnoid Hemorrhagic Stroke. -Chapter 15_Trace elements and Brain Cancer. -Chapter 16_Impact of excess/deficient trace elements on neuronal genomic stability. -Chapter 17_Trace elements in OMICS era. -Chapter 18_Blood markers of oxidative stress in patients with ALS.