Main description:

Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish.

All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.

Contents:

1. Introduction on neuroimmunology

2. Neuroimmune interactions: from bench to bedside

3. Neuroimmunology: translational lessons from zebrafish

4. COVID-19-related neuroinflammation may reveal the triggers for healthy longevity

5. Role of neural-immune dysregulation in the periphery in the development of immune dysfunctions

6. Pericytes, a cell type contributing to immune tolerance and autoimmunity

7. Immunity and cognition

8. Neuroimmunology and sleep

9. Impact of systemic inflammation on neuroinflammation

10. Rare autoimmune and autoinflammatory neurologic disorders

11. Epstein-Barr virus and neuroinflammation

12. The potential role of dietary intervention for the treatment of neuroinflammation

13. Immune dysregulation and neurodegenerative diseases

14. Immunological Aspects of Glaucomatous Optic Neuropathy Etiology and Treatments

15. Imaging characteristics of neuroimmunological disorders

16. Contribution of neuroimaging studies to understanding of immunology and inflammation in epilepsy

17. Bedside to bench side translation with the targeting of the BAFF/APRIL axis in neurological autoimmune disorders

18. New insights on Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) as potential therapeutic target for immune mediated neurological disorders

19. Inflammasome Elements in Epilepsy and Seizures

20. Treatment Approaches to Neuroimmunological Diseases: Therapeutic Candidates Affecting Neuroinflammation