Main description:

This is the first of three volumes in the "Ion Channels & Transporters in Tumor Biology" collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis. The authors highlight the role of the so-called transportome, which is defined by the entirety of ion transporters and ion channels. Thereby, readers will get a better understanding of the impact dysregulated ion transport has on the whole spectrum of cancer types. Cancers display deficiencies in several, sometimes interdependent members of the transportome.
Clinicians will be interested in the fact that controlled expression of ion transport proteins dramatically impacts the life span of cancer patients, as shown in recent studies. These observations offer a promising outlook for biomedical scientists, as members of the transportome could be the tumor markers of tomorrow - both for diagnostic and therapeutic purposes.
As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.

Contents:

Effects of the tumor-environment on ion channels: implication for breast cancer progression

Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, and Ahmed Ahidouch

Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening

Valerio Farfariello, Natalia Prevarskaya, and Dimitra Gkika

Ion channels in Lung Cancer

Etmar Bulk, Luca Matteo Todesca, and Albrecht Schwab

Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer

Giuliano Ciarimboli, Gerit Theil, Joanna Bialek, and Bayram Edemir

Transportome malfunctions and the Hallmarks of Pancreatic Cancer

Qi Ling and Holger Kalthoff

How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer

Christian Stock

Ion Channels in Glioma Malignancy

Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, and 6 Fabio Franciolini

Membrane Transporters and Channels in Melanoma

Ines Boehme, Roland Schoenherr, Jurgen Eberle, and Anja Katrin Bosserhoff

Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application

Nagore Del-Rio-Ibisate, Rocio Granda-Diaz, Juan P. Rodrigo, Sofia T. Menendez, and Juana M. Garcia-Pedrero