Main description:

The first comprehensive and most recent overview of the topic, this ready reference and handbook reviews current knowledge of TAAs, their subclasses, and pinpoints their application areas in medicine. In addition, it emphasizes target identification procedures, the need for an accurate and thorough analysis of the function of TAAs, and the validation of those in clinical settings. The whole is rounded off with an overview of currently approved therapeutic antibodies. The result is a must-have for biologists and oncologists in science, clinics and industry.

Contents:

TUMOUR-ASSOCIATED ANTIGENS (TAAS): SUBCLASSES OF TAAS T cell Antigens in Cancer (A. Paschen) Human Tumour Antigens, Immunosurveillance, and Cancer Vaccines (O.J. Finn) METHODS TO DETECT TAAS Humoral Antigens in Cancer: Serological Identification Methods, Part I: SEREX (M. Pfreundschuh) Humoral Antigens in Cancer: Serological Identification Methods, Part II: Proteomex and AMIDA (B. Seliger, O. Gires) cDNA and Microarray-Based Technologies (F. Marincola, Ena Wang) Detection and Identification of TAA by SELDI-TOF (F. von Eggeling, C. Melle) TAAS AND THEIR USEFULNESS Minor Histocompatibility Antigens and TAAs for Pediatric Cancers (U. Behrends, J. Mautner) TAAs and their Regulation/Epigenetics (M. Maio) Cancer-Testis Antigens (CT-antigens) (J.S. Cebon) Animal Models for TAAs (P. McLaughlin) Epithelial Cell Adhesion Molecule EpCAM in cancer (CD326) (P.A Baeuerle, G. Riethmuller) Carcinoembryonic Antigen CEA (W. Zimmermann, R. Kammerer) Her2/neu and Herceptin (B. Seliger) Epstein-Barr Virus (EBV) Tumour-Associated Antigens (C. Mancao, W. Hammerschmidt) Human Papilloma Virus (HPV) Tumour-Associated Antigens (A. Kaufmann) Circulating TAAs: Biomarkers for Ovarian Cancer Diagnosis (E. Seregni, E. Bombardieri) CLINICAL APPLICATIONS OF TAAS Cancer Vaccines (A. Dalgleish) Peptide Vaccination (D.P. Fairlie) DNA Vaccination: Human Papilloma Virus (T.C. Wu) Adoptive T cell transfer (A. Moosmann, A. Krackhardt)