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The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases

A Doody's Core Title for 2020!

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields.

The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.

Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Contents:

1

Initial approach to the patient: History and physical examination

2

Examination of blood cells

3

Examination of the marrow

4

Consultative Hematology

5

Structure of the marrow and hematopoietic microenvironment

6

The organization and structure of lymphoid tissues

7

Hematology of the fetus and newborn

8

Hematology during pregnancy

9

Hematology in older persons

10

Genetic principles

11

Genomics

12

Epigenetics

13

Cytogenetic and Genetic Abnormalities

14

Metabolism of Hematological Neoplastic Cells

15

Apoptosis and Autophagy

16

Cell cycle regulation and hematological disorders

17

Signal transduction pathways

18

Hematopoietic stem cells, progenitors, and cytokines

19

The inflammatory response

20

Innate immunity

21

Adaptive immunity

22

Pharmacology and toxicity of antineoplastic drugs

23

Hematopoietic stem cell transplantation

24

Treatment of infections in the immunocompromised host

25

Antithrombotic therapy

26

Immune cell therapy

27

Vaccine therapy

28

Therapeutic apheresis: indications, efficacy, and complications

29

Gene transfer for therapy

30

Regenerative Medicine: Multipotential cell therapy for tissue replacement

31

Structure and Composition of the Erythrocyte

Absorb former 30 Composition of Erythrocyte.

32

Erythropoiesis

33

Erythrocytes turnover

34

Clinical manifestations and classification of erythrocyte disorders

35

Aplastic anemia

36

Pure red cell aplasia

37

Anemia of chronic disease

38

Erythropoietic effects of endocrine disorders

39

The congenital dyserythropoietic anemias

40

Paroxysmal nocturnal hemoglobinuria

41

Folate, cobalamin and megaloblastic anemias

42

Iron Metabolism

43

Iron deficiency and overload

44

Anemia resulting from other nutritional deficiencies