Main description:

Yamada s Textbook of Gastroenterology has for 20 years been the most comprehensive gastroenterology reference book, combining an encyclopaedic basic science approach to GI and liver disease with the latest clinical thinking, especially in diagnostic and therapeutic developments.  It is universally respected across the globe.

It has always had an outstanding editor team led by Tachi Yamada, one of the world s leading figures in GI research, and in addition, a hugely impressive team of contributors, each experts in their specific area.  

Now with a new Editor–in–Chief, Dan Podolsky, Professor of Internal Medicine at the University of Texas Southwestern Medical Center,  the 6^th edition of this iconic textbook is modernising and improving in a number of ways:

• Now with free, fully searchable access to the entire digital text with every print purchase.


• A templated chapter approach, including separate chapter templates for a) basic science chapters; b) disease chapters and c) symptom chapters, resulting in more consistency in both structure, content and length of chapters. 


• Far more clinically focused than before by virtue of a brand new section "Principles of Clinical Gastroenterology".  Containing 14 symptom–focused chapters, it will enable doctors to assess their patients in the clinic more effectively than ever.


• Increased coverage of key topics like autoimmune pancreatitis, fecal biomarkers, genetics, IBD, IgG4 systemic disease , Crohn s disease, ulcerative colitis, and eosinophilic esophagitis.


• Downloadable hot topic podcasts from the world s key GI experts.


• Greater emphasis on clinical studies/trials, evidence–based practice, society guidelines, and governmental agencies than before.


• Every reference online, with hyperlinks to Pubmed/CrossRef, rather than ′static′ print references. Key references will be retained in print.


• For more international and global authorship – along with the leading North American figures, the top European and Asian GI experts provide their expertise and insights throughout.

Yamada s Textbook of Gastroenterology 6E is the complete gastroenterology reference book.  With a greater than ever clinical focus, not only does it retain its position as the market leader in terms of basic science coverage, but it also cements itself as an outstanding resource to consult in terms of the clinical management of GI disorders. 
 
Better than ever and with free, fully searchable access to the entire content digitally with the print book, it suits the needs of the modern day gastroenterologist, whether experienced or at the beginning of their career.

Contents:

Contributors

Preface

Foreword by Tadataka Yamada

PART 1 ANATOMY AND DEVELOPMENT

1 Development and differentiation of the gastrointestinal system
Ben Z. Stanger and Daniel K. Podolsky

2 Stem cells and tissue regeneration
Johan H. van Es, Sina Bartfeld and Hans Clevers

3 Esophagus: anatomy and structural anomalies
Ikuo Hirano

4 Stomach and duodenum: anatomy and structural anomalies
Jean–Pierre Raufman and Eric Goldberg

5 Small intestine: anatomy and structural anomalies
Deborah C. Rubin and Anisa Shaker

6 Colon: anatomy and structural anomalies
Jeffrey B. Matthews and Konstantin Umanskiy

7 Pancreas: anatomy and structural anomalies
Kevin Tri Nguyen and Diane M. Simeone

8 Abdominal cavity: anatomy, structural anomalies, and hernias
Kevin Murphy, Michael M. Maher, and Owen J. O Connor.

9 Gallbladder and biliary tract: anatomy and structural anomalies
Theodore H. Welling, III

10 Liver: anatomy, structural anomalies, and cell types
Gary C. Kanel

11 Gastrointestinal blood flow
D. Neil Granger and Thorsten Vowinkel

PART 2 MECHANISMS OF NORMAL AND ABNORMAL GASTROINTESTINAL FUNCTION

A Components

12 Integrative responses of the gastrointestinal tract, pancreas, and liver to a meal
Stephen J. Pandol, Helen E. Raybould and Hal Yee

13 Gastrointestinal hormones and receptors
Laurence J. Miller

14 The brain–gut axis
Qasim Aziz and Adam D Farmer

15 The innervation of the gastrointestinal tract
John B. Furness, Daniel P. Poole, Hyun Jung Cho, Brid Callaghan and Leni R. Rivera

16 Smooth muscle of the gastrointestinal tract
Gabriel M. Makhlouf and Karnam S. Murthy

17 The mucosal immune system and gastrointestinal inflammation
Fabio Cominelli, Kristen O. Arseneau, Matthew J. Hamilton and Richard S. Blumberg

18 Epithelia and gastrointestinal function
Jerrold R. Turner

B Motility

19 Esophageal motor function
Peter J. Kahrilas, John E. Pandolfino and David A. Katzka

20 Gastric motility and gastric emptying
Michael Camilleri

21 Motility of the small intestine and colon
Adil E. Bharucha and William Lee Hasler

22 Biliary tract motility
Gary M. Mawe, Brigitte Lavoie, Peter L. Moses and Maria J. Pozo

C Secretion and absorption

23 Gastric secretion
M. Michael Wolfe and Robert Lowe

24 Small intestine and colon: electrolyte secretion and absorption
Kim E. Barrett and Stephen J. Keely

25 Pancreatic secretion
Chung Owyang and John A. Williams

26 Bile secretion and cholestasis
Andrew P. Feranchak

D Nutrition

27 General nutritional principles
David Alpers and Kevin Cashman

28 Control of appetite/satiety and energy balance
Joel K. Elmquist and  Jay D. Horton

29 Nutrient sensing, digestion, and absorption/assimilation
Eamonn M M Quigley and Shrinivas Bishu

30 Vitamins and minerals
Francis Okeke, Danielle Flug Capalino, Laura Matatese and Gerard E. Mullin

E Miscellaneous

31 Neoplasia of the gastrointestinal tract
Raymond N. DuBois and Ofer Margalit

32 The human intestinal microbiota and microbiome
Omry Koren and Ruth E. Ley

33 Drug metabolism, transport, and pharmacogenomics
Kristina K. Wolf, Brandon T. Gufford, Scott J. Brantley, Paul B. Watkins, and Mary F. Paine

PART 3 PRINCIPLES OF CLINICAL GASTROENTEROLOGY

34 Clinical decision making
Jasmine K. Zia and John Inadomi

35 Approach to the patient with dyspepsia and related functional gastrointestinal complaints
Jan F. Tack

36 Approach to the patient with dysphagia, odynophagia, or noncardiac chest pain
André J.P.M. Smout

37 Approach to the patient with unintentional weight loss
Sreedhar Subramanian and Jonathan M. Rhodes

38 Approach to the patient with nausea and vomiting
William Lee Hasler

39 Approach to the patient with abdominal pain
Pankaj J. Pasricha

40 Approach to the patient with gas and bloating
Satish S.C. Rao  and Yeong Yeh Lee

41 Approach to the patient with diarrhea
Gail A. Hecht, Jonathan Gaspar, and Miguel Malespin

42 Approach to the patient with constipation
Charlene M. Prather

43 Approach to the patient with acute abdomen
Kenneth McQuaid and Courtney B. Sherman

44 Approach to the patient with GI bleeding
Dennis M. Jensen and Kevin A.Ghassemi

45 Approach to the patient with abnormal liver chemistries or jaundice
J. Gregory Fitz

46 Approach to gastrointestinal and liver diseases in pregnancy
Nancy S. Reau and Sumona Saha

47 Genetic counseling for gastrointestinal patients
Richard Boland, Jr. and Laura E. Panos

PART 4 GASTROINTESTINAL DISEASES

A–Esophagus

48 Motility disorders of the esophagus
Peter J. Kahrilas and John E. Pandolfino

49 Gastroesophageal reflux disease
Peter J. Kahrilas, John E. Pandolfino, and Sabine Roman

50 Eosinophilic esophagitis
Yael Haberman Ziv, Margaret H. Collins and Marc E. Rothenberg

51 Esophageal infections and disorders associated with acquired immunodeficiency syndrome
C. Mel Wilcox

52 Barrett esophagus and Esophageal Adenocarcinoma
Stuart J. Spechler, David H. Wang and Rhonda F. Souza

53 Esophageal neoplasms
Anil Rustgi and Adam J. Bass

54 Miscellaneous diseases of the esophagus: foreign bodies, physical injury, and systemic and dermatological diseases
Seth D. Crockett,  Evan S. Dellon and Nicholas J. Shaheen

B–Stomach

55 Disorders of gastric emptying
Henry P. Parkman

56 Peptic ulcer disease
John Christopher Atherton, Richard Ingram and Krishnan Ragunath

57 Zollinger–Ellison syndrome
Robert T. Jensen

58 Gastritis and gastropathy
Mary Kay Washington and Richard Peek

59 Tumors of the stomach
Emad M.  El–Omar and Mairi H McLean

60 Miscellaneous diseases of the stomach
Tamas Gonda and Yanghee Woo

C–Small intestine

61 Dysmotility of the small intestine and colon
Lawrence Szarka

62 Bacterial, viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections
Mitchell B. Cohen

63 Chronic infections of the small intestine
Billy Bourke and Seamus Hussey

64 Celiac disease
Daniel A. Leffler, Melinda Dennis, and Ciarán P. Kelly

65 Disorders of epithelial transport, metabolism, and digestion in the small intestine
Eugene B. Chang

66 Bacterial overgrowth
Eamonn M. M. Quigley

67 Short bowel syndrome and small bowel transplantation
John K. DiBaise and Debra Sudan

68 Tumors of the small intestine
Barbara H. Jung and Maria Rosario Ferreira

69 Miscellaneous diseases of the small intestine
Marc S. Levin

D–Inflammatory Bowel Disease

70 Inflammatory Bowel Diseases: Pathogenesis
Ashwin N. Ananthakrishnan, Ramnik J. Xavier and Daniel K. Podolsky

71 Ulcerative colitis
Stephen B. Hanauer and Daniel K. Podolsky

72 Crohn′s disease: clinical manifestation and management
Stephan R. Targan and Gil Melmed

73 Surgical treatment of inflammatory bowel disease
Alessandro Fichera, Emily Finlayson, Leon Maggiori and Fabrizio Michelassi

74 Microscopic colitis and other miscellaneous inflammatory and structural disorders of the colon
Eugene Yen and Darrell S. Pardi

E–Colon

75 Irritable bowel syndrome
Lin Chang and Elizabeth J. Videlock

76 Diverticular disease of the colon
Robin C. Spiller and David J. Humes

77 Polyps of the colon and rectum
Daniel C. Chung and John J. Garber III

78 Malignant tumors of the colon
Andrew T. Chan and Jay Luther

79 Polyposis syndromes
Randall W. Burt and Kory Jasperson

80 Colorectal cancer screening
Uri Ladabaum

81 Anorectal diseases
Arnold Wald and Adil Bharucha

F–Pancreas

82 Acute pancreatitis
Hana Algül, Andreas Weber, Wolfgang Huber and Roland M. Schmid II

83 Autoimmune pancreatitis
Suresh T. Chari and Philip A. Hart

84 Chronic pancreatitis
Joachim Mössner, Albrecht Hoffmeister and Julia Mayerle

85 Hereditary diseases of the pancreas
David C. Whitcomb

86 Cystic lesions of the pancreas
James Farrell

87 Adenocarcinoma of the pancreas
Andrew M. Lowy and Paul T. Fanta

88 Endocrine and other tumors of the pancreas
Daniel C. Chung and Peter Carolan

G–Gallbladder and biliary tract

89 Gallstones
Piero Portincasa and David Q.–H. Wang

90 Primary sclerosing cholangitis and other cholangiopathies
Konstantinos N. Lazaridis and Jayant A. Talwalkar

91 Cystic diseases of the liver and biliary tract
Shelly C. Lu and James Buxbaum

92 Tumors of the biliary tract
Tushar Patel

93 Sphincter of Oddi dysfunction and postcholecystectomy syndrome
John O. Clarke and Anthony N. Kalloo

H–Liver

94 Acute viral hepatitis
Marc G. Ghany and T. Jake Liang

95 Chronic hepatitis B viral infection
Jules Dienstag and Karin Andersson

96 Hepatitis C virus infection
Raymond T. Chung and Andrew Tai

97 Drug–induced liver disease
William M. Lee

98 Acute liver failure
William M. Lee

99 Autoimmune hepatitis
Michael P. Manns and Richard Taubert

100 Primary biliary cirrhosis
Dwain L. Thiele and Marlyn J. Mayo

101 Hemochromatosis
Paul C. Adams

102 Metabolic diseases of the liver
Shikha S. Sundaram and Ronald J. Sokol

103 Alcoholic liver diseases
Jose Altamirano, Eric E. Orman and Ramon Bataller

104 Nonalcoholic fatty liver disease
M. Shadab Siddiqui and Arun J. Sanyal

105 Hepatic Fibrosis and Cirrhosis
Don C. Rockey

106 Ascites and its complications
Guadalupe Garcia–Tsao

107 Central nervous system and pulmonary complications of end–stage liver disease
Jasmohan Bajaj and Scott C. Matherly

108 Liver transplantation
Robert S. Brown, Jr. and Alyson Fox

109 Hepatocellular carcinoma
Amit Singal and Jorge A. Marrero

110 Liver abscess
David S. Raiford and Roman E. Perri

111 Vascular diseases of the liver
Laurie D. DeLeve and Susana Seijo

I–Miscellaneous

112 Intraabdominal abscesses and fistulae
Peter Irving and Nyree Griffin

113 Diseases of the peritoneum, retroperitoneum, mesentery, and omentum
Jennifer W. Harris and B. Mark Evers

114 Nutritional support
Joshua D. Novak and Steven J. D.O′Keefe

115 Obesity: treatment and complications
Louis A. Chaptini and Steven R. Peikin

116 Bariatric surgery
Danny O. Jacobs and Obos Ekhaese

117 Eating disorders
Henry C. Lin and Eric E. Stone

118 Complications of AIDS and other immunodeficiency states
Phillip Doyle Smith and Edward N. Janoff

119 Immunological disorders: (a) Food Allergy and hypersensitivity
Jonathan O′B Hourihane

120 Immunological disorders: (b) GI complications of organ transplantation and small bowel transplantation
Fergus Shanahan and Paula O Leary

121 Parasitic diseases: protozoa
Ellen Li and Samuel Stanley

122 Parasitic diseases: helminths
Thormika Keo, John Leung and Joel Weinstock

123 Gastrointestinal and hepatic manifestations of specific genetic disorders
Judy Cho

124 Gastrointestinal manifestations of systemic diseases
Eran Israeli and Charles N Bernstein

125 Skin lesions associated with gastrointestinal and liver diseases
Kim Yancey and Travis W. Vandergriff

126 Oral manifestations of gastrointestinal diseases
Vidyasagar Ramappa and Yashwant R. Mahida

127 Gastrointestinal vascular malformations and neoplasms
Anne C. Travis and Joshua R. Korzenik

128 Intestinal ischemia and vasculitides
Juan–Ramón Malagelada and Carolina Malagelada

129 Radiation injury in the gastrointestinal tract
Steven M. Cohn, Alda Vidrich and Stephen J. Bickston

130 Complementary and alternative medicine in gastroenterology
Anthony J. Lembo and Andrea Bollom

PART 5 DIAGNOSTIC AND THERAPEUTIC MODALITIES IN GASTROENTEROLOGY

A–Endoscopic

131 General approach to endoscopy: sedation, monitoring, and preparation
Douglas K. Rex and Hala Fatima

132 Upper gastrointestinal endoscopy
William R. Brugge and Abdurrahman Kadayifci

133 Capsule and small bowel endoscopy
Jonathan A. Leighton and Shabana F. Pasha

134 Colonoscopy and flexible sigmoidoscopy
Peter H. Rubin, Steven Naymagon, Christopher B. Williams and Jerome D. Waye

135 Endoscopic retrograde cholangiopancreatography: diagnostic and therapeutic
Martin L. Freeman and Mustafa Arain

136 Gastrointestinal dilation and stent placement
Richard A. Kozarek and Shayan Irani

137 Endoscopic approaches to enteral nutrition
Todd H. Baron and Ryan J. Law

138 Management of upper gastrointestinal hemorrhage related to portal hypertension
Zhiping Li and Tinsay A. Woreta

139 Endoscopic diagnosis and treatment of nonvariceal upper gastrointestinal hemorrhage
Joseph Leung and Anne Thai

140 Endoscopic therapy for polyps and tumors
Mouen A. Khashab and Heiko Pohl

141 Laparoscopy and laparotomy
Ricardo Zorron and Gustavo Carvalho

142 Submucosal endoscopy: diagnostic and therapeutic
Christopher J. Gostout

143 Natural orifice translumenal endoscopic surgery (NOTES)
Vivek Kumbhari and Anthony N. Kalloo

B–Imaging

144 Plain and contrast radiology
Marc S. Levine and Stephen Rubesin

145 Transabdominal sonography
Ulrike M. Hamper, Stephanie Coquia and Linda Chu

146 Endoscopic ultrasonography: diagnostic and therapeutic
Marcia Irene Canto and Mouen A. Khashab

147 Computed tomography of the gastrointestinal tract
Siva P. Raman, Karen M. Horton, Pamela T. Johnson, Alec J. Megibow, and Elliot K. Fishman

148 Magnetic resonance imaging in the gastrointestinal tract
Donald G. Mitchell and Diane Bergin

149 Positron emission tomography
Manuela Matesan, Jonathan Sham, James Park, and Satoshi Minoshima

150 Radionuclide imaging in the gastrointestinal tract
Harvey A. Ziessman

151 Abdominal angiography
Kyung Jae Cho

152 Interventional radiology
Todd Schlachter, Julius Chapiro, Rafael Duran, Vania Tacher, Camila Zamboni, Luke J. Higgins and Jean–Francois Geschwind

153 Confocal laser endomicroscopy
Helmut Neumann and Ralf Kiesslich

C–Pathology

154 Liver biopsy and histopathological diagnosis
Sugantha Govindarajan

155 Endoscopic mucosal biopsy: histopathological interpretation
Elizabeth A. Montgomery

D–Gastrointestinal function studies

156 Tests of gastric and exocrine pancreatic function and absorption
Joseph R. Pisegna and Deepinder Goyal

Index